Summary of study ST001256

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000842. The data can be accessed directly via it's Project DOI: 10.21228/M8V694 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  |  Download all metabolite data  |  Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data (Contains raw data)
Study IDST001256
Study TitleMetabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens
Study SummaryDuchenne muscular dystrophy is caused by genetic defects in the gene encoding dystrophin and leads to progressive muscle degeneration. Glucocorticoid steroids are current mainstay pharmacological regimen to decrease muscle inflammation and prolong the ambulatory period in these patients, but daily intake of glucocorticoids like prednisone and deflazacort causes adverse side effects like osteoporosis, adrenal suppression, insulin resistance and obesity. Intermittent steroid dosing has been proposed as alternative to maintain benefits and limit side effects, but a detailed understanding of the mechanisms underpinning the regimen-specific effects in muscle is still missing. Here we explore how once-daily versus once-weekly prednisone (4 week-long treatment) affect the metabolomic landscape in mdx mouse muscle (genetic model of Duchenne muscular dystrophy; DBA/2J background) through metabolomics profiling.
Institute
Northwestern University
Last NameQuattrocelli
First NameMattia
Address303 East Superior St, SQBRC 5-500, Chicago, IL, 60611, USA
Emailmattia.quattrocelli@northwestern.edu
Phone3125037450
Submit Date2019-09-26
Num Groups3
Total Subjects9
Num Males9
Raw Data AvailableYes
Raw Data File Type(s).raw
Analysis Type DetailLC-MS
Release Date2020-01-06
Release Version1
Mattia Quattrocelli Mattia Quattrocelli
https://dx.doi.org/10.21228/M8V694
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA091299McN-Mat-20180411-07daily prednisone
SA091300McN-Mat-20180411-09daily prednisone
SA091301McN-Mat-20180411-08daily prednisone
SA091302McN-Mat-20180411-03vehicle
SA091303McN-Mat-20180411-02vehicle
SA091304McN-Mat-20180411-01vehicle
SA091305McN-Mat-20180411-05weekly prednisone
SA091306McN-Mat-20180411-04weekly prednisone
SA091307McN-Mat-20180411-06weekly prednisone
Showing results 1 to 9 of 9
  logo