Summary of Study ST001339

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000915. The data can be accessed directly via it's Project DOI: 10.21228/M8DQ2M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001339
Study TitleDisruption of Redox Balance Enhances the Effects of BRAF-inhibitors in Melanoma
Study SummarySpecifically, we report that drug-insensitive melanoma cells can maintain higher levels of antioxidant metabolites to withstand the lethal effects of drugs. By extending our analysis to other melanoma subtypes in the TCGA, we show that elevated redox capacity could indeed be a general feature of melanoma. Our results suggest that redox vulnerabilities could be exploited for therapeutic benefits and identify unsuspected combination targets to enhance the effects of BRAFi in pan-melanoma.
Institute
Vanderbilt University
Last NameCodreanu
First NameSimona
Address1234 Stevenson Center Lane
Emailsimona.codreanu@vanderbilt.edu
Phone6158758422
Submit Date2020-03-31
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-03-31
Release Version1
Simona Codreanu Simona Codreanu
https://dx.doi.org/10.21228/M8DQ2M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id genotype treatment
SA097565SD5aresistant DMSO
SA097566SD5bresistant DMSO
SA097567SD4aresistant DMSO
SA097568SD1aresistant DMSO
SA097569SD4bresistant DMSO
SA097570SD3bresistant DMSO
SA097571SD1bresistant DMSO
SA097572SD2bresistant DMSO
SA097573SD2aresistant DMSO
SA097574SD3aresistant DMSO
SA097575SP4bresistant PLX4720
SA097576SP5aresistant PLX4720
SA097577SP5bresistant PLX4720
SA097578SP4aresistant PLX4720
SA097579SP2aresistant PLX4720
SA097580SP1aresistant PLX4720
SA097581SP3bresistant PLX4720
SA097582SP1bresistant PLX4720
SA097583SP2bresistant PLX4720
SA097584SP3aresistant PLX4720
SA097585WD4bsensitive DMSO
SA097586WD5asensitive DMSO
SA097587WD5bsensitive DMSO
SA097588WD4asensitive DMSO
SA097589WD1asensitive DMSO
SA097590WD3bsensitive DMSO
SA097591WD2asensitive DMSO
SA097592WD1bsensitive DMSO
SA097593WD3asensitive DMSO
SA097594WD2bsensitive DMSO
SA097595WP4bsensitive PLX4720
SA097596WP5bsensitive PLX4720
SA097597WP4asensitive PLX4720
SA097598WP5asensitive PLX4720
SA097599WP2bsensitive PLX4720
SA097600WP1asensitive PLX4720
SA097601WP1bsensitive PLX4720
SA097602WP2asensitive PLX4720
SA097603WP3asensitive PLX4720
SA097604WP3bsensitive PLX4720
Showing results 1 to 40 of 40
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