Summary of Study ST001384

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000948. The data can be accessed directly via it's Project DOI: 10.21228/M8540T This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001384
Study TitlePlasmodium falciparum increased time in circulation underlies persistent asymptomatic infection in the dry season
Study SummaryThe dry season is a major challenge for Plasmodium falciparum parasites in many malaria endemic regions, where water availability limits mosquitoes to only part of the year. How P. falciparum bridges two transmission seasons months apart, without being cleared by the host or compromising host survival is poorly understood. Here we show that low levels of P. falciparum parasites persist in the blood of asymptomatic Malian individuals during the 5- to 6-month dry season, rarely causing symptoms and minimally affecting the host immune response. Parasites isolated during the dry season are transcriptionally distinct from those of subjects with febrile malaria in the transmission season, reflecting longer circulation within each replicative cycle, of parasitized erythrocytes without adhering to the vascular endothelium. Low parasite levels during the dry season are not due to impaired replication, but rather increased splenic clearance of longer-circulating infected erythrocytes. We propose that P. falciparum virulence in areas of seasonal malaria transmission is regulated so that the parasite decreases its endothelial binding capacity, allowing increased splenic clearance and enabling several months of subclinical parasite persistence.
Institute
Pennsylvania State University
Last NameLlinas
First NameManuel
AddressW126 Millennium Science Complex, University Park, PENNSYLVANIA, 16802, USA
Emailmanuel@psu.edu
Phone(814) 867-3527
Submit Date2020-05-25
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2020-08-20
Release Version1
Manuel Llinas Manuel Llinas
https://dx.doi.org/10.21228/M8540T
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Genotype
SA101065blank1Blank
SA101066blank3Blank
SA101067blank2Blank
SA101068blank4Blank
SA101069b332MAL
SA101070b322MAL
SA101071b262MAL
SA101072b385MAL
SA101073b459MAL
SA101074b224MAL
SA101075b443MAL
SA101076b400MAL
SA101077b391MAL
SA101078b371MAL
SA101079b170MAL
SA101080b161MAL
SA101081poolb1MAL Pool
SA101082poolb2MAL Pool
SA101083poolb3MAL Pool
SA101084a320May
SA101085a326May
SA101086a325May
SA101087a308May
SA101088a351May
SA101089a244May
SA101090a448May
SA101091a388May
SA101092a373May
SA101093a355May
SA101094a357May
SA101095a334May
SA101096poola3May Pool
SA101097poola1May Pool
SA101098poola2May Pool
SA101099qc1Pool
SA101100qc2Pool
SA101101qc3Pool
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