Summary of Study ST001429
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000981. The data can be accessed directly via it's Project DOI: 10.21228/M8WD7R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001429 |
Study Title | MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with Host Cell Factor-1 |
Study Summary | MYC is an oncoprotein transcription factor that is overexpressed in the majority cancers. Although MYC itself is considered undruggable, it may be possible to inhibit MYC by targeting the co-factors it uses to drive oncogenic gene expression patterns. Here, we use loss- and gain- of function approaches to interrogate how one MYC co-factor—Host Cell Factor (HCF)-1—contributes to MYC activity in a Burkitt lymphoma setting. We identify high-confidence direct targets of the MYC–HCF-1 interaction that are regulated through a recruitment-independent mechanism, including genes that control mitochondrial function and rate-limiting steps for ribosome biogenesis and translation. We describe how these gene expression events impact cell growth and metabolism, and demonstrate that the MYC–HCF-1 interaction is essential for tumor maintenance in vivo. This work highlights the MYC–HCF-1 interaction as a focal point for development of novel anti-cancer therapies. |
Institute | Vanderbilt University |
Last Name | Codreanu |
First Name | Simona |
Address | 1234 Stevenson Center Lane |
simona.codreanu@vanderbilt.edu | |
Phone | 6158758422 |
Submit Date | 2020-07-15 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2021-01-19 |
Release Version | 1 |
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Factors:
Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | genotype |
---|---|---|
SA120690 | 4A-2 | 4A |
SA120691 | 4A-4 | 4A |
SA120692 | 4A-5 | 4A |
SA120693 | 4A-1 | 4A |
SA120694 | 4A-3 | 4A |
SA120695 | VP-3 | VP |
SA120696 | VP-4 | VP |
SA120697 | VP-5 | VP |
SA120698 | VP-2 | VP |
SA120699 | VP-1 | VP |
SA120700 | WT-2 | WT |
SA120701 | WT-1 | WT |
SA120702 | WT-4 | WT |
SA120703 | WT-3 | WT |
SA120704 | WT-5 | WT |
Showing results 1 to 15 of 15 |