Summary of Study ST001526

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001027. The data can be accessed directly via it's Project DOI: 10.21228/M8Z41B This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001526
Study TitleMitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan
Study SummaryThe intrinsic aerobic capacity of an organism is thought to play a role in aging and longevity. Maximal respiratory rate capacity, a metabolic performance measure, is one of the best predictors of cardiovascular- and all-cause mortality. Rats selectively bred for high-(HCR) vs. low-(LCR) intrinsic running-endurance capacity have up to 31% longer lifespan. We found that positive changes in indices of mitochondrial health in cardiomyocytes (respiratory reserve, maximal respiratory capacity, resistance to mitochondrial permeability transition, autophagy/mitophagy, higher lipids-over-glucose utilization) are uniformly associated with the extended longevity in HCR vs. LCR female rats. Cross-sectional heart metabolomics revealed pathways from lipid metabolism in the heart which were significantly enriched by a select group of strain dependent metabolites, consistent with enhanced lipids utilization by HCR cardiomyocytes. Heart-liver-serum metabolomics further revealed shunting of lipidic substrates between liver and heart via serum during aging. Thus, mitochondrial health in cardiomyocytes is associated with extended longevity in rats with higher intrinsic exercise capacity, and likely these findings can be translated to other populations as predictors of outcomes of health and survival.
Institute
National Institute on Aging
DepartmentCardioprotection Section
LaboratoryLaboratory of Cardiovascular Science
Last NameSollott
First NameSteven
AddressLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA
Emailsollotts@grc.nia.nih.gov
Phone410-558-8657
Submit Date2020-10-23
Raw Data AvailableYes
Raw Data File Type(s)cdf
Analysis Type DetailGC-MS
Release Date2020-12-01
Release Version1
Steven Sollott Steven Sollott
https://dx.doi.org/10.21228/M8Z41B
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id local_sample_id treatment Tissue
SA1286041-H_027control heart
SA1286052-H_028control heart
SA1286066-H_030control heart
SA12860725-H_038control heart
SA1286085-H_029control heart
SA12860926-H_039control heart
SA12861014-H_032control heart
SA12861124-H_037control heart
SA12861221-H_034control heart
SA12861315-H_033control heart
SA12861422-H_035control heart
SA12861513-H_031control heart
SA12861623-H_036control heart
SA12861726-L_024control liver
SA12861827-L_025control liver
SA12861924-L_022control liver
SA12862028-L_026control liver
SA12862125-L_023control liver
SA1286224-L_004control liver
SA1286236-L_006control liver
SA12862423-L_021control liver
SA1286255-L_005control liver
SA1286263-L_003control liver
SA1286272-L_002control liver
SA1286281-L_001control liver
SA12862921-L_019control liver
SA12863013-L_011control liver
SA12863114-L_012control liver
SA12863211-L_009control liver
SA12863310-L_008control liver
SA12863422-L_020control liver
SA12863515-L_013control liver
SA12863612-L_010control liver
SA12863716-L_014control liver
SA12863820-L_018control liver
SA12863919-L_017control liver
SA12864018-L_016control liver
SA12864117-L_015control liver
SA1286429-L_007control liver
SA128597_007control serum
SA128598_010control serum
SA128601_009control serum
SA128602_008control serum
SA128643Rat 1_040control serum
SA128644MA-9_062control serum
SA128645MA-8_061control serum
SA128646Rat 2_041control serum
SA128647Rat 5_044control serum
SA128648MA-7_060control serum
SA128649Rat 6_045control serum
SA128650Rat 4_043control serum
SA128651Rat 3_042control serum
SA128652HC-6_051control serum
SA128653HC-5_050control serum
SA128654HC-4_049control serum
SA128655C2-HC-2_047control serum
SA128656C2-HC-1_046control serum
SA128657HC-7_052control serum
SA128658HC-8_053control serum
SA128659MA-12_065control serum
SA128660MA-11_064control serum
SA128661MA-10_063control serum
SA128662MA-5_058control serum
SA128478Heart HCR18730_040HCR heart
SA128479HEART_HCR18895_016HCR heart
SA128480HEART_HCR18927_017HCR heart
SA128481HEART_HCR18947_018HCR heart
SA128482HEART_HCR18871_015HCR heart
SA128483HEART_HCR19139_061HCR heart
SA128484HEART_HCR19157_058HCR heart
SA128485HEART_HCR19158_059HCR heart
SA128486HEART_HCR18866_013HCR heart
SA128487Heart HCR18659_018HCR heart
SA128488HEART_HCR18883_014HCR heart
SA128489HEART_HCR19153_060HCR heart
SA128490HEART_HCR19143_063HCR heart
SA128491Heart HCR18731_014HCR heart
SA128492Heart HCR18730_015HCR heart
SA128493Heart HCR18698_017HCR heart
SA128494HEART_HCR19140_062HCR heart
SA128495Heart HCR18729_016HCR heart
SA128496LIVER_HCR18927_005HCR liver
SA128497LIVER_HCR18947_006HCR liver
SA128498LIVER_HCR19139_049HCR liver
SA128499LIVER_HCR19140_050HCR liver
SA128500LIVER_HCR18895_004HCR liver
SA128501LIVER_HCR18883_002HCR liver
SA128502Liver HCR18731_038HCR liver
SA128503LIVER_HCR18866_001HCR liver
SA128504LIVER_HCR18871_003HCR liver
SA128505LIVER_HCR19143_051HCR liver
SA128506LIVER_HCR19153_048HCR liver
SA128507_002HCR liver
SA128508_005HCR liver
SA128509_004HCR liver
SA128510Liver HCR18698_008HCR liver
SA128511Liver HCR18729_007HCR liver
SA128512Liver HCR18730_006HCR liver
SA128513LIVER_HCR19157_046HCR liver
SA128514LIVER_HCR19158_047HCR liver
Showing page 1 of 2     Results:    1  2  Next     Showing results 1 to 100 of 185
  logo