Summary of Study ST001692

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001088. The data can be accessed directly via it's Project DOI: 10.21228/M82H6Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001692
Study TitlePerfluoroalkyl substances and lipid composition in human milk
Study TypeCHEAR Study
Study SummaryPFAS are widely used in commercial products, and so humans have consistent exposure to them via oil- and water-resistant consumer products, fire- fighting foam, and industrial surfactants 1,2. The four PFASs commonly detected in blood, perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) 3,4, are present in drinking water supplies both in northern New England as well as in 27 states nationally 5-8. Animal models shows that PFASs have can have effects on both the endocrine system and on adiposity 9-12. Epidemiological evidence shows that the presence of PFASs in maternal serum is associated with changes in maternal serum lipid and cholesterol composition 13,14. Similarly, serum levels of PFAS in adolescents have been associated with increases in serum cholesterol 15. These findings raise interesting questions about the association of PFAS and lipids in human milk. Research has shown the PFASs are present in human milk 16-18, and human milk is composed primarily of lipids 19. However, the relation between PFAS in milk and milk composition is unclear. The chemical and compositional profiles of breast milk are important because of the potential effects on the developing infant. The developmental origins of health and disease hypothesis suggests that early life exposures, such as toxins and nutrients via breast milk, have lasting effects on health, particularly obesity outcomes 20. In fact, some studies have shown associations between PFAS in maternal serum and infant birth weight and later childhood BMI 14,21. Our study will help to better illuminate the potential effects of maternal exposure to PFASs on infant exposure, both through direct transmission into breast milk and indirectly via influence on the lipid profiles of milk. To investigate how early life exposure to perfluoroalkyl substances (PFAS) may affect childhood health outcomes as mediated through breast milk, we propose the following specific aims: 1. Characterize the levels of PFAS in breast milk samples (n=495) in the NHBCS; 2. Characterize the lipid profiles of breast milk samples (n=495) in the NHBCS; 3. Test the relation between PFAS concentration and breast milk lipid profiles; and 4. Test the association between PFAS concentrations in maternal plasma collected during pregnancy with paired breast milk samples (n=100).
Institute
Icahn School of Medicine at Mount Sinai
DepartmentDepartment of Environmental Medicine and Public Health
LaboratoryMount Sinai CHEAR Untargeted Laboratory Hub
Last NameWalker
First NameDouglas
AddressAtran Building RM AB3-39, 1428 Madison Ave
Emaildouglas.walker@mssm.edu
Phone212-241-9891
Submit Date2021-02-10
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2022-03-11
Release Version1
Douglas Walker Douglas Walker
https://dx.doi.org/10.21228/M82H6Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Class
SA156659NIST1954_HRE0010_03_006QAQC
SA156660NIST1954_HRE0010_02_010QAQC
SA156661NIST1953_HRE0010_02_009QAQC
SA156662NIST1953_HRE0010_03_005QAQC
SA156663NIST1954_HRE0010_02_004QAQC
SA156664NIST1953_HRE0010_03_001QAQC
SA156665NIST1953_HRE0010_02_003QAQC
SA156666NIST1953_HRE0010_06_003QAQC
SA156667NIST1954_HRE0010_05_006QAQC
SA156668NIST1953_HRE0010_04_009QAQC
SA156669NIST1954_HRE0010_04_010QAQC
SA156670NIST1953_HRE0010_05_001QAQC
SA156671NIST1953_HRE0010_05_005QAQC
SA156672NIST1953_HRE0010_01_005QAQC
SA156673NIST1953_HRE0010_04_005QAQC
SA156674NIST1954_HRE0010_02_002QAQC
SA156675NIST1954_HRE0010_06_004QAQC
SA156676NIST1954_HRE0010_03_002QAQC
SA156677NIST1954_HRE0010_04_008QAQC
SA156678NIST1953_HRE0010_03_003QAQC
SA156679NIST1954_HRE0010_03_004QAQC
SA156680NIST1953_HRE0010_01_009QAQC
SA156681NIST1954_HRE0010_01_010QAQC
SA156682NIST1953_HRE0010_02_001QAQC
SA156683NIST1953_HRE0010_04_007QAQC
SA156684NIST1954_HRE0010_05_008QAQC
SA156685NIST1953_HRE0010_05_007QAQC
SA156686NIST1954_HRE0010_01_008QAQC
SA156687NIST1953_HRE0010_01_007QAQC
SA156688NIST1954_HRE0010_05_002QAQC
SA156689NIST1954_HRE0010_06_002QAQC
SA156690NIST1953_HRE0010_06_001QAQC
SA156691NIST1953_HRE0010_05_009QAQC
SA156692NIST1954_HRE0010_05_010QAQC
SA156693NIST1954_HRE0010_04_006QAQC
SA156694NIST1954_HRE0010_01_006QAQC
SA156695NIST1954_HRE0010_05_004QAQC
SA156696NIST1954_HRE0010_04_002QAQC
SA156697NIST1953_HRE0010_03_009QAQC
SA156698NIST1954_HRE0010_03_010QAQC
SA156699NIST1954_HRE0010_01_004QAQC
SA156700NIST1953_HRE0010_01_003QAQC
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SA156702NIST1953_HRE0010_02_007QAQC
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SA156704NIST1954_HRE0010_06_006QAQC
SA156705NIST1954_HRE0010_02_006QAQC
SA156706NIST1953_HRE0010_06_005QAQC
SA156707NIST1954_HRE0010_04_004QAQC
SA156708NIST1953_HRE0010_03_007QAQC
SA156709NIST1953_HRE0010_04_003QAQC
SA156710NIST1953_HRE0010_02_005QAQC
SA156711NIST1954_HRE0010_01_002QAQC
SA156712NIST1954_HRE0010_06_008QAQC
SA156713NIST1953_HRE0010_01_001QAQC
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SA156715NIST1953_HRE0010_06_007QAQC
SA156716NIST1954_HRE0010_03_008QAQC
SA156717C-23NF4-BR-00Study_Sample
SA156718C-23L79-BR-00Study_Sample
SA156719C-23XV9-BR-00Study_Sample
SA156720C-241M6-BR-00Study_Sample
SA156721C-23CP3-BR-00Study_Sample
SA156722C-23T89-BR-00Study_Sample
SA156723C-23Z75-BR-00Study_Sample
SA156724C-23W37-BR-00Study_Sample
SA156725C-23AL4-BR-00Study_Sample
SA156726C-23C60-BR-00Study_Sample
SA156727C-23JB7-BR-00Study_Sample
SA156728C-23AS8-BR-00Study_Sample
SA156729C-23PB1-BR-00Study_Sample
SA156730C-24240-BR-00Study_Sample
SA156731C-23A96-BR-00Study_Sample
SA156732C-23P34-BR-00Study_Sample
SA156733C-23WT4-BR-00Study_Sample
SA156734C-23PT1-BR-00Study_Sample
SA156735C-23UK6-BR-00Study_Sample
SA156736C-23H81-BR-00Study_Sample
SA156737C-23C37-BR-00Study_Sample
SA156738C-23JG6-BR-00Study_Sample
SA156739C-23JT7-BR-00Study_Sample
SA156740C-23KB6-BR-00Study_Sample
SA156741C-23B95-BR-00Study_Sample
SA156742C-243K8-BR-00Study_Sample
SA156743C-23R32-BR-00Study_Sample
SA156744C-23NS5-BR-00Study_Sample
SA156745C-23L46-BR-00Study_Sample
SA156746C-23WQ1-BR-00Study_Sample
SA156747C-23TR2-BR-00Study_Sample
SA156748C-23N69-BR-00Study_Sample
SA156749C-23PP0-BR-00Study_Sample
SA156750C-23RP8-BR-00Study_Sample
SA156751C-23RJ1-BR-00Study_Sample
SA156752C-23GM6-BR-00Study_Sample
SA156753C-23CF5-BR-00Study_Sample
SA156754C-240L9-BR-00Study_Sample
SA156755C-23KN9-BR-00Study_Sample
SA156756C-23NG2-BR-00Study_Sample
SA156757C-23DL1-BR-00Study_Sample
SA156758C-23FL9-BR-00Study_Sample
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