Summary of Study ST001738

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001112. The data can be accessed directly via it's Project DOI: 10.21228/M8ZM49 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001738
Study TitleAdipoAtlas: A Reference Lipidome for Human White Adipose Tissue
Study SummaryObesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders. Remodelling of WAT lipidome in obesity and associated comorbidities can explain disease etiology and provide valuable diagnostic and prognostic markers. To support understanding of WAT lipidome remodelling at molecular level, we performed in-depth lipidomics profiling of human subcutaneous and visceral WAT of lean and obese individuals. Tissue-tailored preanalytical and analytical workflows allowed accurate identification and semi-absolute quantification of 1636 and 737 lipid molecular species, respectively, and summarized here in a form of human WAT reference lipidome. Deep lipidomic profiling allowed to identify main lipid (sub)classes undergoing depot/phenotype specific remodelling. Furthermore, previously unanticipated diversity of WAT ceramides was uncovered. AdipoAtlas reference lipidome will serve as a data-rich resource for development of WAT-specific high-throughput methods and as a scaffold for systems medicine data integration.
Institute
University of Leipzig
DepartmentFaculty for Chemistry and Mineralogy, Biotechnological-Biomedical Center
LaboratoryFedorova Lab
Last NameFedorova
First NameMaria
AddressDeutscher Platz 5
Emailmaria.fedorova@bbz.uni-leipzig.de
Phone03419731336
Submit Date2021-01-11
Num Groups4
Study CommentsPools of subcutaneous and visceral white adipose tissue were generated from lean patients (BMI < 25; n=5) and obese (BMI > 40; n=81)
Publicationshttps://doi.org/10.1016/j.xcrm.2021.100407
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2021-04-23
Release Version1
Maria Fedorova Maria Fedorova
https://dx.doi.org/10.21228/M8ZM49
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Depot location Phenotype
SA162926SAT (lean)3Subcutaneous lean
SA162927SAT (lean)2Subcutaneous lean
SA162928SAT (lean)1Subcutaneous lean
SA162929SAT (ob)1Subcutaneous obese
SA162930SAT (ob)2Subcutaneous obese
SA162931SAT (ob)5Subcutaneous obese
SA162932SAT (ob)3Subcutaneous obese
SA162933SAT (ob)4Subcutaneous obese
SA162934SAT (ob)6Subcutaneous obese
SA162935VAT (lean)1Visceral lean
SA162936VAT (lean)2Visceral lean
SA162937VAT (lean)3Visceral lean
SA162938VAT (ob)6Visceral obese
SA162939VAT (ob)1Visceral obese
SA162940VAT (ob)2Visceral obese
SA162941VAT (ob)3Visceral obese
SA162942VAT (ob)4Visceral obese
SA162943VAT (ob)5Visceral obese
Showing results 1 to 18 of 18
  logo