Summary of Study ST001888

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001047. The data can be accessed directly via it's Project DOI: 10.21228/M8C68D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001888
Study TitleA Metabolome Atlas of the Aging Mouse Brain (Study part II)
Study SummaryThe mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remains poorly understood. To start bridging this gap, we generated a metabolome atlas of the aging wildtype male and female mouse brain from 10 anatomical regions spanning from adolescence to old age. We combined data from three chromatography-based mass spectrometry assays and structurally annotated 1,547 metabolites to reveal the underlying architecture of aging-induced changes in the brain metabolome. Overall differences between sexes were minimal. We found 99% of all metabolites to significantly differ between brain regions in at least one age group. We also discovered that 97% of the metabolome showed significant changes with respect to age groups. For example, we identified a shift in sphingolipid patterns during aging that is related to myelin remodeling in the transition from adolescent to aging brains. This shift was accompanied by large changes in overall signature in a range of other metabolic pathways. We found clear metabolic similarities in brain regions that were functionally related such as brain stem, cerebrum and cerebellum. In cerebrum, metabolic correlation patterns got markedly weaker in the transition from adolescent to adulthood, whereas the overall correlation patterns between all regions reflected a decreased brain segregation at old age. We were also able to map metabolic changes to gene and protein brain atlases to link molecular changes to metabolic brain phenotypes. Metabolic profiles can be investigated via https://mouse.atlas.metabolomics.us/. This new resource enables brain researchers to link new metabolomic studies to a foundation data set.
Institute
University of California, Davis
DepartmentGenome Center
LaboratoryWest Coast Metabolomics Center
Last NameDing
First NameJun
Address451 East Health Science Drive, Davis, CA, 95616, USA
Emailjunding@ucdavis.edu
Phone773-326-5420
Submit Date2021-07-25
Raw Data AvailableYes
Raw Data File Type(s)cdf, raw(Thermo)
Analysis Type DetailGC-MS/LC-MS
Release Date2021-08-30
Release Version1
Jun Ding Jun Ding
https://dx.doi.org/10.21228/M8C68D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Brain region Gender
SA175310900483-015-165Basal ganglia Female
SA175311900483-010-110Basal ganglia Female
SA175312900483-011-121Basal ganglia Female
SA175313900483-016-176Basal ganglia Female
SA175314900483-014-154Basal ganglia Female
SA175315900483-009-099Basal ganglia Female
SA175316900483-013-143Basal ganglia Female
SA175317900483-012-132Basal ganglia Female
SA175318900483-014-066Basal ganglia Male
SA175319900483-011-033Basal ganglia Male
SA175320900483-015-077Basal ganglia Male
SA175321900483-012-044Basal ganglia Male
SA175322900483-016-088Basal ganglia Male
SA175323900483-013-055Basal ganglia Male
SA175324900483-010-022Basal ganglia Male
SA175325900483-009-011Basal ganglia Male
SA175326900483-010-103Cerebellum Female
SA175327900483-011-114Cerebellum Female
SA175328900483-013-136Cerebellum Female
SA175329900483-012-125Cerebellum Female
SA175330900483-014-147Cerebellum Female
SA175331900483-016-169Cerebellum Female
SA175332900483-015-158Cerebellum Female
SA175333900483-009-092Cerebellum Female
SA175334900483-013-048Cerebellum Male
SA175335900483-011-026Cerebellum Male
SA175336900483-009-004Cerebellum Male
SA175337900483-010-015Cerebellum Male
SA175338900483-015-070Cerebellum Male
SA175339900483-016-081Cerebellum Male
SA175340900483-012-037Cerebellum Male
SA175341900483-014-059Cerebellum Male
SA175342900483-009-090Cerebral cortex Female
SA175343900483-012-123Cerebral cortex Female
SA175344900483-011-112Cerebral cortex Female
SA175345900483-014-145Cerebral cortex Female
SA175346900483-016-167Cerebral cortex Female
SA175347900483-015-156Cerebral cortex Female
SA175348900483-013-134Cerebral cortex Female
SA175349900483-010-101Cerebral cortex Female
SA175350900483-016-079Cerebral cortex Male
SA175351900483-010-013Cerebral cortex Male
SA175352900483-013-046Cerebral cortex Male
SA175353900483-012-035Cerebral cortex Male
SA175354900483-014-057Cerebral cortex Male
SA175355900483-009-002Cerebral cortex Male
SA175356900483-011-024Cerebral cortex Male
SA175357900483-015-068Cerebral cortex Male
SA175358900483-013-135Hippocampus Female
SA175359900483-010-102Hippocampus Female
SA175360900483-012-124Hippocampus Female
SA175361900483-009-091Hippocampus Female
SA175362900483-014-146Hippocampus Female
SA175363900483-015-157Hippocampus Female
SA175364900483-011-113Hippocampus Female
SA175365900483-016-168Hippocampus Female
SA175366900483-009-003Hippocampus Male
SA175367900483-013-047Hippocampus Male
SA175368900483-011-025Hippocampus Male
SA175369900483-014-058Hippocampus Male
SA175370900483-012-036Hippocampus Male
SA175371900483-016-080Hippocampus Male
SA175372900483-015-069Hippocampus Male
SA175373900483-010-014Hippocampus Male
SA175374900483-012-128Hypothalamus Female
SA175375900483-015-161Hypothalamus Female
SA175376900483-013-139Hypothalamus Female
SA175377900483-011-117Hypothalamus Female
SA175378900483-010-106Hypothalamus Female
SA175379900483-016-172Hypothalamus Female
SA175380900483-009-095Hypothalamus Female
SA175381900483-014-150Hypothalamus Female
SA175382900483-013-051Hypothalamus Male
SA175383900483-014-062Hypothalamus Male
SA175384900483-009-007Hypothalamus Male
SA175385900483-012-040Hypothalamus Male
SA175386900483-011-029Hypothalamus Male
SA175387900483-015-073Hypothalamus Male
SA175388900483-010-018Hypothalamus Male
SA175389900483-016-084Hypothalamus Male
SA175390900483-013-141Medulla Female
SA175391900483-010-108Medulla Female
SA175392900483-016-174Medulla Female
SA175393900483-011-119Medulla Female
SA175394900483-009-097Medulla Female
SA175395900483-012-130Medulla Female
SA175396900483-014-152Medulla Female
SA175397900483-015-163Medulla Female
SA175398900483-015-075Medulla Male
SA175399900483-014-064Medulla Male
SA175400900483-012-042Medulla Male
SA175401900483-016-086Medulla Male
SA175402900483-011-031Medulla Male
SA175403900483-010-020Medulla Male
SA175404900483-009-009Medulla Male
SA175405900483-013-053Medulla Male
SA175406900483-016-170Midbrain Female
SA175407900483-011-115Midbrain Female
SA175408900483-010-104Midbrain Female
SA175409900483-009-093Midbrain Female
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