Summary of Study ST001903

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001198. The data can be accessed directly via it's Project DOI: http://dx.doi.org/10.21228/M8VD7F This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001903
Study TitleEffect of ketogenic diet on the plasma and tumor metabolome of melanoma-bearing mice
Study TypeMetabolomics analysis
Study SummaryGrowing evidence supports the use of low-carbohydrate/high-fat ketogenic diets (KDs) together with standard therapies to improve cancer treatment outcomes. However, conflicting data exist regarding the efficacy of KDs in melanoma, the deadliest skin cancer. Here, we show that two different KD formulations effectively reduced tumor growth in immunocompromised mice bearing genetically and metabolically heterogeneous human melanoma xenografts. Furthermore, the KDs exerted a metastasis-reducing effect in an immunocompetent syngeneic melanoma mouse model. Ketone bodies did not directly influence melanoma cell proliferation; therefore, we performed an in-depth metabolomics analysis using the MxP® Quant 500 kit combined with a acylcarnitine assay (biocrates life sciences ag)to elucidate potential anti-tumor mechanisms in vivo. Targeted analysis of plasma and tumor metabolomes revealed distinct changes in amino acid metabolism induced by the KDs. Moreover, the KDs increased sphingomyelin synthesis and hydroxylation of certain lipids. Thus, KDs simultaneously affect multiple metabolic pathways to create an unfavorable environment for melanoma cell proliferation, supporting their potential as a complementary nutritional approach to melanoma therapy.
Institute
University Hospital of the Paracelsus Medical University Salzburg
Last NameWeber
First NameDaniela
AddressMüllner Hauptstraße 48, 5020 Salzburg, Austria
Emaild.weber@salk.at
Phone0043 57255 26274
Submit Date2021-08-10
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS/MS(Dir. Inf.)
Release Date2022-07-11
Release Version1
Daniela Weber Daniela Weber
http://dx.doi.org/10.21228/M8VD7F
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Sample description Tissue
SA232171plasma # 237A375 CTRL plasma
SA232172plasma # 235A375 CTRL plasma
SA232173plasma # 238A375 CTRL plasma
SA232174plasma # 239A375 CTRL plasma
SA232175plasma # 227A375 CTRL plasma
SA232176plasma # 234A375 CTRL plasma
SA232177plasma # 236A375 CTRL plasma
SA232178plasma # 233A375 CTRL plasma
SA232179plasma # 228A375 CTRL plasma
SA232180plasma # 230A375 CTRL plasma
SA232181plasma # 229A375 CTRL plasma
SA232182plasma # 231A375 CTRL plasma
SA232183plasma # 232A375 CTRL plasma
SA232184tumor # 236A375 CTRL tumor
SA232185tumor # 234A375 CTRL tumor
SA232186tumor # 233A375 CTRL tumor
SA232187tumor # 238A375 CTRL tumor
SA232188tumor # 239A375 CTRL tumor
SA232189tumor # 237A375 CTRL tumor
SA232190tumor # 235A375 CTRL tumor
SA232191tumor # 230A375 CTRL tumor
SA232192tumor # 232A375 CTRL tumor
SA232193tumor # 228A375 CTRL tumor
SA232194tumor # 229A375 CTRL tumor
SA232195tumor # 231A375 CTRL tumor
SA232196tumor # 227A375 CTRL tumor
SA232197plasma # 261A375 LCT-MCT plasma
SA232198plasma # 262A375 LCT-MCT plasma
SA232199plasma # 259A375 LCT-MCT plasma
SA232200plasma # 263A375 LCT-MCT plasma
SA232201plasma # 253A375 LCT-MCT plasma
SA232202plasma # 258A375 LCT-MCT plasma
SA232203plasma # 255A375 LCT-MCT plasma
SA232204plasma # 254A375 LCT-MCT plasma
SA232205plasma # 257A375 LCT-MCT plasma
SA232206plasma # 256A375 LCT-MCT plasma
SA232207tumor # 261A375 LCT-MCT tumor
SA232208tumor # 259A375 LCT-MCT tumor
SA232209tumor # 262A375 LCT-MCT tumor
SA232210tumor # 258A375 LCT-MCT tumor
SA232211tumor # 253A375 LCT-MCT tumor
SA232212tumor # 263A375 LCT-MCT tumor
SA232213tumor # 254A375 LCT-MCT tumor
SA232214tumor # 255A375 LCT-MCT tumor
SA232215tumor # 256A375 LCT-MCT tumor
SA232216tumor # 257A375 LCT-MCT tumor
SA232217plasma # 246A375 LCT plasma
SA232218plasma # 247A375 LCT plasma
SA232219plasma # 249A375 LCT plasma
SA232220plasma # 251A375 LCT plasma
SA232221plasma # 245A375 LCT plasma
SA232222plasma # 244A375 LCT plasma
SA232223plasma # 240A375 LCT plasma
SA232224plasma # 241A375 LCT plasma
SA232225plasma # 243A375 LCT plasma
SA232226plasma # 252A375 LCT plasma
SA232227plasma # 248A375 LCT plasma
SA232228tumor # 241A375 LCT tumor
SA232229tumor # 244A375 LCT tumor
SA232230tumor # 240A375 LCT tumor
SA232231tumor # 251A375 LCT tumor
SA232232tumor # 252A375 LCT tumor
SA232233tumor # 245A375 LCT tumor
SA232234tumor # 243A375 LCT tumor
SA232235tumor # 246A375 LCT tumor
SA232236tumor # 250A375 LCT tumor
SA232237tumor # 248A375 LCT tumor
SA232238tumor # 249A375 LCT tumor
SA232239tumor # 247A375 LCT tumor
SA232240plasma # 281WM3000 CTRL plasma
SA232241plasma # 280WM3000 CTRL plasma
SA232242plasma # 279WM3000 CTRL plasma
SA232243plasma # 278WM3000 CTRL plasma
SA232244plasma # 282WM3000 CTRL plasma
SA232245plasma # 288WM3000 CTRL plasma
SA232246plasma # 287WM3000 CTRL plasma
SA232247plasma # 277WM3000 CTRL plasma
SA232248plasma # 286WM3000 CTRL plasma
SA232249plasma # 285WM3000 CTRL plasma
SA232250plasma # 284WM3000 CTRL plasma
SA232251plasma # 283WM3000 CTRL plasma
SA232252tumor # 279WM3000 CTRL tumor
SA232253tumor # 284WM3000 CTRL tumor
SA232254tumor # 277WM3000 CTRL tumor
SA232255tumor # 283WM3000 CTRL tumor
SA232256tumor # 285WM3000 CTRL tumor
SA232257tumor # 288WM3000 CTRL tumor
SA232258tumor # 286WM3000 CTRL tumor
SA232259tumor # 287WM3000 CTRL tumor
SA232260tumor # 281WM3000 CTRL tumor
SA232261tumor # 282WM3000 CTRL tumor
SA232262tumor # 280WM3000 CTRL tumor
SA232263tumor # 278WM3000 CTRL tumor
SA232264plasma # 305WM3000 LCT-MCT plasma
SA232265plasma # 304WM3000 LCT-MCT plasma
SA232266plasma # 303WM3000 LCT-MCT plasma
SA232267plasma # 310WM3000 LCT-MCT plasma
SA232268plasma # 302WM3000 LCT-MCT plasma
SA232269plasma # 308WM3000 LCT-MCT plasma
SA232270plasma # 311WM3000 LCT-MCT plasma
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