Summary of Study ST001935

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001224. The data can be accessed directly via it's Project DOI: 10.21228/M8H12N This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001935
Study TitleMetabolomic profiling of spontaneous macaque model for diabetes mellitus
Study SummaryThe prevalence of diabetes mellitus has been increasing for decades worldwide. To develop safe and potent therapeutics, insights into the mechanisms underlying its pathogenesis are urgently needed. We reported the multi-omics profiling of the liver and sera of both peripheral blood and hepatic portal vein blood from Macaca fascicularis with spontaneous diabetes mellitus with a chow diet. The other two groups of the monkeys fed with chow diet and high-sugar high-fat (HSHF) diet, respectively, were included for comparison. These multi-omics datasets can provide a comprehensive picture of the molecular changes caused by diabetes in primates. Analyses of various omics datasets revealed the alterations of high consistency. Correlation between transcripts and proteins derived from the same genes was observed across individuals for most genes, especially the ones of differential expression. As a result, we found that distinct patterns of the metabolome, proteome, and transcriptome between spontaneous diabetes and HSHF diet-induced diabetes compared with healthy individuals.
Institute
Xiamen University
Last NameYang
First NameZhu
AddressOEW901, Oen Hall Building West Wing,, Ho Sin Hang Campus, Hong Kong Baptist University
Emailyangzhu@gmail.com
Phone(+852)34115162
Submit Date2021-09-18
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailGC-MS
Release Date2022-02-19
Release Version1
Zhu Yang Zhu Yang
https://dx.doi.org/10.21228/M8H12N
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Macaca fascicularis (Factor headings shown in green)

mb_sample_id local_sample_id Condition Tissue
SA181877HFD-HPVB-1HFHS HPVB
SA181878HFD-HPVB-3HFHS HPVB
SA181879HFD-HPVB-2HFHS HPVB
SA181880HFD-Liver-2HFHS Liver
SA181881HFD-Liver-3HFHS Liver
SA181882HFD-Liver-1HFHS Liver
SA181883HFD-PB1HFHS PB
SA181884HFD-PB3HFHS PB
SA181885HFD-PB2HFHS PB
SA181886Nomal-HPVB-1NC HPVB
SA181887Nomal-HPVB-3NC HPVB
SA181888Nomal-HPVB-2NC HPVB
SA181889Normal-Liver-2NC Liver
SA181890Normal-Liver-3NC Liver
SA181891Normal-Liver-1NC Liver
SA181892Nomal-PB-1NC PB
SA181893Nomal-PB-3NC PB
SA181894Nomal-PB-2NC PB
SA181895Diabetes-HPVB-3sDM HPVB
SA181896Diabetes-HPVB-1sDM HPVB
SA181897Diabetes-HPVB-2sDM HPVB
SA181898Diabetes-Liver-3sDM Liver
SA181899Diabetes-Liver-1sDM Liver
SA181900Diabetes-Liver-2sDM Liver
SA181901Diabetes-PB1sDM PB
SA181902Diabetes-PB3sDM PB
SA181903Diabetes-PB2sDM PB
Showing results 1 to 27 of 27
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