Summary of Study ST001961

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001248. The data can be accessed directly via it's Project DOI: 10.21228/M8D41C This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001961
Study TitleMetabolomics of brown adipose tissue in murine heart failure model
Study Typeuntargeted CE-TOF/MS metabolomic profiling
Study SummaryBrown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the changes of metabolites, we conducted the CE-TOF/MS analysis using BAT from TAC (thoracic aortic constriction) or sham-operated mice. In BAT from TAC-operated mice, we found increase of choline and glycerophosphorylcholine and a decrease of phosphorylcholine, suggesting that BAT dysfunction induces the disorientation of choline metabolism.
Institute
Juntendo University
DepartmentDepartment of Cardiovascular Biology and Medicine
Last NameYoshida
First NameYohko
Address2-1-1, Hongo, Bunkyo-ku, Tokyo, Tokyo, 1138421, Japan
Emailyohko105@yahoo.co.jp
Phone+81-3-3813-3111
Submit Date2021-10-13
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailMS(Dir. Inf.)
Release Date2022-11-01
Release Version1
Yohko Yoshida Yohko Yoshida
https://dx.doi.org/10.21228/M8D41C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Group
SA184620--
SA1846214BSham-operated
SA1846226BSham-operated
SA1846233BSham-operated
SA1846241BSham-operated
SA1846252BSham-operated
SA18462612BTAC-operated
SA18462711BTAC-operated
SA1846289BTAC-operated
SA1846297BTAC-operated
SA18463010BTAC-operated
Showing results 1 to 11 of 11
  logo