Summary of Study ST001983

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001259. The data can be accessed directly via it's Project DOI: 10.21228/M8ZX2N This work is supported by NIH grant, U2C- DK119886.

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Study IDST001983
Study TitleMetabolomic Fingerprinting of Human High Grade Serous Ovarian Carcinoma Cell Lines
Study SummaryFocusing on defining the metabolomic basis of intratumoral heterogeneity in ovarian cancer, the metabolic diversity of a panel of high grade serous ovarian carcinoma (HGSOC) cell-lines we investigated using a metabolomics platform that interrogate 731 compounds. Metabolic fingerprinting followed by 2-dimensional and 3-dimensional principal component analysis defined the heterogeneity of the HGSOC cells and clustered them into five distinct metabolic groups. An overall increase in the metabolites associated with aerobic glycolysis and phospholipid metabolism were observed in the majority of the cancer cells. A preponderant increase in the levels of metabolites involved in trans-sulfuration and glutathione synthesis was also observed. Subsets of HGSOC cells showed an increase in the levels of 5-Hydroxytryptamine, gamma-aminobutyric acid, or glutamate, pointing to their potential role as oncometabolites. In summary, our results identify increased glycolysis, phospholipid metabolism and amino acid metabolism with the resultant increase in the levels of 5-Hydoxytryptamine, GABA, and Glutamate as metabolomic correlates underlying the heterogeneity of ovarian cancer cell lines.
Institute
University of Oklahoma Health Sciences Center
DepartmentCell Biology
LaboratoryDanny N Dhanasekaran
Last NameJayaraman
First NameMuralidharan
Address975 NE 10th street, BRC1470, Oklahoma City, Oklahoma, 73104, USA
EmailMuralidharan-Jayaraman@ouhsc.edu
Phone4052718001 x 30492
Submit Date2021-09-20
Num Groups2
Total Subjects30
Num Females15
Study CommentsOvarian cancer cell lines
Analysis Type DetailLC-MS
Release Date2021-12-01
Release Version1
Muralidharan Jayaraman Muralidharan Jayaraman
https://dx.doi.org/10.21228/M8ZX2N
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA185669OUHSC-22No treatment
SA185670OUHSC-23No treatment
SA185671OUHSC-21No treatment
SA185672OUHSC-19No treatment
SA185673OUHSC-18No treatment
SA185674OUHSC-24No treatment
SA185675OUHSC-20No treatment
SA185676OUHSC-25No treatment
SA185677OUHSC-29No treatment
SA185678OUHSC-30No treatment
SA185679OUHSC-28No treatment
SA185680OUHSC-27No treatment
SA185681OUHSC-26No treatment
SA185682OUHSC-17No treatment
SA185683OUHSC-16No treatment
SA185684OUHSC-6No treatment
SA185685OUHSC-7No treatment
SA185686OUHSC-5No treatment
SA185687OUHSC-4No treatment
SA185688OUHSC-2No treatment
SA185689OUHSC-3No treatment
SA185690OUHSC-8No treatment
SA185691OUHSC-9No treatment
SA185692OUHSC-14No treatment
SA185693OUHSC-15No treatment
SA185694OUHSC-13No treatment
SA185695OUHSC-12No treatment
SA185696OUHSC-10No treatment
SA185697OUHSC-11No treatment
SA185698OUHSC-1No treatment
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