Summary of Study ST002010

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001274. The data can be accessed directly via it's Project DOI: 10.21228/M81Q4Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002010
Study TitleChemoresistant Ovarian Cancer Global Metabolomics
Study SummaryChemoresistance remains the major barrier to effective ovarian cancer treatment. The molecular features and associated biological functions of this phenotype remain poorly understood. We developed carboplatin resistant cell line models using OVCAR5 and CaOV3 cell lines with the aim of identifying chemoresistance-specific molecular features. Mass spectrometry analysis was used to analyse the metabolome of these cell lines and was able to separate these populations based on their molecular features. It revealed signaling and metabolic perturbations in chemoresistant cell lines. A comprehensive analysis of a larger patient cohort, including advanced in vitro and in vivo models, promises to help better understand the molecular mechanisms of chemo-resistance and associated enhancement of migration and invasion.
Institute
University of South Australia
Last NameAcland
First NameMitchell
AddressCnr North Terrace and Morphett Street, Adelaide SA 5000
Emailmitch.acland@gmail.com
Phone0425460869
Submit Date2021-12-05
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-12-22
Release Version1
Mitchell Acland Mitchell Acland
https://dx.doi.org/10.21228/M81Q4Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Chemoresistance Status
SA188294QC_ov_2N/A
SA188295DMEM_IST_2N/A
SA188296Blank_1N/A
SA188297QC_ov_3N/A
SA188298RPMI_IST_1N/A
SA188299Blank_2N/A
SA188300QC_ov_1N/A
SA188301RPMI_IST_2N/A
SA188302Blank_3N/A
SA188303DMEM_IST_1N/A
SA188304CaOV3_CBPR_3Resistant
SA188305OVCAR5_CBPR_2Resistant
SA188306OVCAR5_CBPR_3Resistant
SA188307CaOV3_CBPR_1Resistant
SA188308CaOV3_CBPR_2Resistant
SA188309OVCAR5_CBPR_1Resistant
SA188310CaOV3_Parent_3Sensitive
SA188311OVCAR5_Parent_1Sensitive
SA188312OVCAR5_Parent_2Sensitive
SA188313OVCAR5_Parent_3Sensitive
SA188314CaOV3_Parent_1Sensitive
SA188315CaOV3_Parent_2Sensitive
Showing results 1 to 22 of 22
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