Summary of Study ST002104
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001333. The data can be accessed directly via it's Project DOI: 10.21228/M8DM7G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002104 |
| Study Title | Chemoresistant Cancer Cell Lines are Characterized by Migratory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations |
| Study Type | Biomedical research |
| Study Summary | Our analysis was able to separate chemoresistant cells from their parental cells based on their metabolomic and proteomic features and identified altered biological processes and pathways which are of further interest. Preliminary investigation of patient-derived cells highlighted the need to perform broad biological and molecular analyses, compre-hensive in vitro and in vivo studies, using a larger patient cohort to achieve a deeper and clinically relevant characterization of the molecular drivers of chemoresistance. |
| Institute | Future Industries Institute |
| Laboratory | Manuela Klingler-Hoffmann |
| Last Name | Acland |
| First Name | Mitchell |
| Address | X Building, Mawson Lakes South Australia 5095 |
| mitch.acland@gmail.com | |
| Phone | 0448671141 |
| Submit Date | 2022-02-06 |
| Num Groups | 4 |
| Total Subjects | 12 |
| Num Males | NA |
| Num Females | NA |
| Study Comments | OVCAR5 and CaOV3 cell lines and their carboplatin resistant cell lines |
| Publications | Chemoresistant Cancer Cell Lines are Characterized by Migra-tory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-03-29 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | conditions |
|---|---|---|
| SA201528 | CaOV3_Parent_2 | CaOV3 cell line |
| SA201529 | CaOV3_Parent_3 | CaOV3 cell line |
| SA201530 | CaOV3_Parent_1 | CaOV3 cell line |
| SA201531 | CaOV3_CBPR_3 | CaOV3 cell line CBPR mutation |
| SA201532 | CaOV3_CBPR_1 | CaOV3 cell line CBPR mutation |
| SA201533 | CaOV3_CBPR_2 | CaOV3 cell line CBPR mutation |
| SA201543 | DMEM_IST_2 | culture media for CaOV3 |
| SA201544 | DMEM_IST_1 | culture media for CaOV3 |
| SA201545 | RPMI_IST_1 | culture media for OVCAR5 |
| SA201546 | RPMI_IST_2 | culture media for OVCAR5 |
| SA201534 | Blank_1 | Extraction blank |
| SA201535 | Blank_2 | Extraction blank |
| SA201536 | Blank_3 | Extraction blank |
| SA201540 | OVCAR5_Parent_3 | OVCAR5_cell line |
| SA201541 | OVCAR5_Parent_2 | OVCAR5_cell line |
| SA201542 | OVCAR5_Parent_1 | OVCAR5_cell line |
| SA201537 | OVCAR5_CBPR_2 | OVCAR5 cell line CBPR mutation |
| SA201538 | OVCAR5_CBPR_3 | OVCAR5 cell line CBPR mutation |
| SA201539 | OVCAR5_CBPR_1 | OVCAR5 cell line CBPR mutation |
| SA201547 | QC_ov_3 | pooled QC |
| SA201548 | QC_ov_2 | pooled QC |
| SA201549 | QC_ov_1 | pooled QC |
| Showing results 1 to 22 of 22 |
