Summary of Study ST002153
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001366. The data can be accessed directly via it's Project DOI: 10.21228/M85115 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST002153 |
| Study Title | Data from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274 |
| Study Summary | Recently, we showed that administration of B. breve MCC1274 reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS. |
| Institute | Morinaga milk industry CO., LTD. |
| Department | Next generation science institute |
| Laboratory | Frontier research section |
| Last Name | Ohno |
| First Name | Kazuya |
| Address | 1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan |
| kazuya-oono443@morinagamilk.co.jp | |
| Phone | 81462523067 |
| Submit Date | 2022-04-18 |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-10-03 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Model | Intervention |
|---|---|---|---|
| SA206357 | AT-1 | Alzheimer’s disease model | B. breve MCC1274 |
| SA206358 | AT-2 | Alzheimer’s disease model | B. breve MCC1274 |
| SA206359 | AT-3 | Alzheimer’s disease model | B. breve MCC1274 |
| SA206360 | AT-4 | Alzheimer’s disease model | B. breve MCC1274 |
| SA206361 | AC-3 | Alzheimer’s disease model | Saline |
| SA206362 | AC-4 | Alzheimer’s disease model | Saline |
| SA206363 | AC-2 | Alzheimer’s disease model | Saline |
| SA206364 | AC-1 | Alzheimer’s disease model | Saline |
| SA206365 | WT-1 | Wild type | B. breve MCC1274 |
| SA206366 | WT-3 | Wild type | B. breve MCC1274 |
| SA206367 | WT-2 | Wild type | B. breve MCC1274 |
| SA206368 | WT-4 | Wild type | B. breve MCC1274 |
| SA206369 | WC-2 | Wild type | Saline |
| SA206370 | WC-3 | Wild type | Saline |
| SA206371 | WC-4 | Wild type | Saline |
| SA206372 | WC-1 | Wild type | Saline |
| Showing results 1 to 16 of 16 |
