Summary of Study ST002236

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001426. The data can be accessed directly via it's Project DOI: 10.21228/M8D42R This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002236
Study TitleThe impact of IgE in gut and serum metabolomes in a murine experimental model of allergic enteritis
Study TypeCase-control study
Study SummaryThe pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma, and anaphylaxis, partly due to difficulty in the access to intestinal tissues and because of a highly complex interplay between microbiota and intestinal mucosa. Importantly, a high level of IgE is a poor prognostic factor in gastrointestinal allergies. This study aimed to investigate how IgE influences the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock-in (IgEki) mice expressing high levels of IgE. Ovalbumin-sensitized and egg-white diet fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulation.
Institute
Institute of Applied Molecular Medicine
Last NameZubeldia-Varela
First NameElisa
AddressAvda. Monteprincipe s/n 28668 Boadilla del Monte, Madrid, España
Emailelisa.zubeldiavarela@ceu.es
PhoneTlf: 91 372 47 00 ext. 14675
Submit Date2022-07-19
Num Groups4 groups: BALB/c wild type (WT) and IgE knock-in mice (C.Ighg1tm1.1Pyu) in the BALB/c background, both sensitised and non-sensitised to ovalbumin.
Total Subjects29
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailGC-MS/LC-MS
Release Date2022-08-10
Release Version1
Elisa Zubeldia-Varela Elisa Zubeldia-Varela
https://dx.doi.org/10.21228/M8D42R
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Genotype Ovalbumin sensitisation
SA213049WT (Only EW) 2FBALB/c wild type Non-sensitised to ovalbumin
SA213050WT (Only EW) 3FBALB/c wild type Non-sensitised to ovalbumin
SA213051WT (Only EW) 1SBALB/c wild type Non-sensitised to ovalbumin
SA213052WT (Only EW) 1FBALB/c wild type Non-sensitised to ovalbumin
SA213053WT (Only EW) 7SBALB/c wild type Non-sensitised to ovalbumin
SA213054WT (Only EW) 3SBALB/c wild type Non-sensitised to ovalbumin
SA213055WT (Only EW) 2SBALB/c wild type Non-sensitised to ovalbumin
SA213056WT (Only EW) 6FBALB/c wild type Non-sensitised to ovalbumin
SA213057WT (Only EW) 4FBALB/c wild type Non-sensitised to ovalbumin
SA213058WT (Only EW) 7FBALB/c wild type Non-sensitised to ovalbumin
SA213059WT (Only EW) 5SBALB/c wild type Non-sensitised to ovalbumin
SA213060WT (Only EW) 6SBALB/c wild type Non-sensitised to ovalbumin
SA213061WT (Only EW) 5FBALB/c wild type Non-sensitised to ovalbumin
SA213062WT (Only EW) 4SBALB/c wild type Non-sensitised to ovalbumin
SA213063WT (OVA_EW) 3FBALB/c wild type Sensitised to ovalbumin
SA213064WT (OVA_EW) 3SBALB/c wild type Sensitised to ovalbumin
SA213065WT (OVA_EW) 2SBALB/c wild type Sensitised to ovalbumin
SA213066WT (OVA_EW) 2FBALB/c wild type Sensitised to ovalbumin
SA213067WT (OVA_EW) 4FBALB/c wild type Sensitised to ovalbumin
SA213068WT (OVA_EW) 1FBALB/c wild type Sensitised to ovalbumin
SA213069WT (OVA_EW) 1SBALB/c wild type Sensitised to ovalbumin
SA213070WT (OVA_EW) 4SBALB/c wild type Sensitised to ovalbumin
SA213071WT (OVA_EW) 5FBALB/c wild type Sensitised to ovalbumin
SA213072WT (OVA_EW) 7SBALB/c wild type Sensitised to ovalbumin
SA213073WT (OVA_EW) 6SBALB/c wild type Sensitised to ovalbumin
SA213074WT (OVA_EW) 7FBALB/c wild type Sensitised to ovalbumin
SA213075WT (OVA_EW) 6FBALB/c wild type Sensitised to ovalbumin
SA213076WT (OVA_EW) 5SBALB/c wild type Sensitised to ovalbumin
SA213077IgEki (Only EW) 3FIgE knock-in mice Non-sensitised to ovalbumin
SA213078IgEki (Only EW) 4FIgE knock-in mice Non-sensitised to ovalbumin
SA213079IgEki (Only EW) 3SIgE knock-in mice Non-sensitised to ovalbumin
SA213080IgEki (Only EW) 1SIgE knock-in mice Non-sensitised to ovalbumin
SA213081IgEki (Only EW) 4SIgE knock-in mice Non-sensitised to ovalbumin
SA213082IgEki (Only EW) 2FIgE knock-in mice Non-sensitised to ovalbumin
SA213083IgEki (Only EW) 2SIgE knock-in mice Non-sensitised to ovalbumin
SA213084IgEki (Only EW) 6SIgE knock-in mice Non-sensitised to ovalbumin
SA213085IgEki (Only EW) 7SIgE knock-in mice Non-sensitised to ovalbumin
SA213086IgEki (Only EW) 1FIgE knock-in mice Non-sensitised to ovalbumin
SA213087IgEki (Only EW) 7FIgE knock-in mice Non-sensitised to ovalbumin
SA213088IgEki (Only EW) 6FIgE knock-in mice Non-sensitised to ovalbumin
SA213089IgEki (Only EW) 5SIgE knock-in mice Non-sensitised to ovalbumin
SA213090IgEki (Only EW) 5FIgE knock-in mice Non-sensitised to ovalbumin
SA213091IgEki (OVA_EW) 8SIgE knock-in mice Sensitised to ovalbumin
SA213092IgEki (OVA_EW) 3FIgE knock-in mice Sensitised to ovalbumin
SA213093IgEki (OVA_EW) 3SIgE knock-in mice Sensitised to ovalbumin
SA213094IgEki (OVA_EW) 2SIgE knock-in mice Sensitised to ovalbumin
SA213095IgEki (OVA_EW) 2FIgE knock-in mice Sensitised to ovalbumin
SA213096IgEki (OVA_EW) 1FIgE knock-in mice Sensitised to ovalbumin
SA213097IgEki (OVA_EW) 1SIgE knock-in mice Sensitised to ovalbumin
SA213098IgEki (OVA_EW) 4FIgE knock-in mice Sensitised to ovalbumin
SA213099IgEki (OVA_EW) 4SIgE knock-in mice Sensitised to ovalbumin
SA213100IgEki (OVA_EW) 7FIgE knock-in mice Sensitised to ovalbumin
SA213101IgEki (OVA_EW) 7SIgE knock-in mice Sensitised to ovalbumin
SA213102IgEki (OVA_EW) 6SIgE knock-in mice Sensitised to ovalbumin
SA213103IgEki (OVA_EW) 6FIgE knock-in mice Sensitised to ovalbumin
SA213104IgEki (OVA_EW) 5FIgE knock-in mice Sensitised to ovalbumin
SA213105IgEki (OVA_EW) 5SIgE knock-in mice Sensitised to ovalbumin
SA213106IgEki (OVA_EW) 8FIgE knock-in mice Sensitised to ovalbumin
Showing results 1 to 58 of 58
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