Summary of Study ST002828

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001770. The data can be accessed directly via it's Project DOI: 10.21228/M8XB0Q This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002828
Study TitleRole of the Afferent Lymph as an Immunological Conduit to Analyze Tissue Antigenic and Inflammatory Load - metabolomics
Study SummaryThe intestinal barrier, and the gut-associated lymphoid tissue, are the interface of the host-microbiome/pathogens interactions and, its disruption, has been associated with a series of inflammatory, autoimmune, and degenerative diseases. Herein we performed the analysis of the pre-nodal mesenteric lymph at steady state and following disruption of the intestinal barrier to map the antigenic and pro-inflammatory load in both mice and human subjects with inflammatory bowel disease. The antigenic signature of gastrointestinal tissue inflammation was reflected in the mesenteric nodal dendritic-cells (DC)-MHCII-eluted immunopeptidome, in a tissue specific manner, when compared to the DC-eluted-MHCII-peptidome from cervical lymph nodes. Pro-inflammatory and microbiome-derived by-products, such as amino acids, deoxy sugars, component of the bacterial wall and other immunomodulators of the gut-brain axis, were found in the afferent lymph following damage to the gut epithelium. Our data points to the relevance of the lymphatic fluid to probe the tissue-specific antigenic and inflammatory load transported to the draining lymph node.
Institute
University of Colorado Denver
Last NameHaines
First NameJulie
Address12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA
Emailjulie.haines@cuanschutz.edu
Phone3037243339
Submit Date2023-08-21
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2024-08-21
Release Version1
Julie Haines Julie Haines
https://dx.doi.org/10.21228/M8XB0Q
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Factor
SA3058632Acontrol afferent
SA3058649Acontrol afferent
SA30586513Acontrol afferent
SA30586614Acontrol afferent
SA3058671Acontrol afferent
SA30586813Econtrol efferent
SA30586914Econtrol efferent
SA3058702Econtrol efferent
SA3058719Econtrol efferent
SA3058721Econtrol efferent
SA3058515ADSS afferent
SA3058526ADSS afferent
SA30585316ADSS afferent
SA3058543ADSS afferent
SA3058557ADSS afferent
SA3058564ADSS afferent
SA3058575EDSS efferent
SA3058584EDSS efferent
SA3058593EDSS efferent
SA3058606EDSS efferent
SA3058617EDSS efferent
SA30586216EDSS efferent
Showing results 1 to 22 of 22
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