Summary of Study ST003026

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001880. The data can be accessed directly via it's Project DOI: 10.21228/M8Q72K This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003026
Study TitleUntargeted Metabolomics Reveals Unique Biomolecular Signatures in Overweight and Obesity Using UHPLC-ESI-QTOF-MS Analysis
Study TypeLC/MS/MS
Study SummaryAims: Obesity poses a multifaceted challenge to global public health, impacting individuals and society in various ways. Apart from the heightened susceptibility to chronic conditions such as diabetes, cardiovascular diseases, obesity significantly escalates healthcare costs. Effective public health strategies are essential for addressing issues related to early detection, diagnosis, and personalized treatment plans. This emphasizes the crucial need for a deep understanding of biochemical pathways, patient monitoring, and prognosis. In this context, metabolomics has become a valuable approach, focusing on the identification of metabolites in biofluids and tissues. Main Methods: In this study, an untargeted metabolomics-based method was employed to investigate metabolomic changes and their relationship to pathways in overweight and obese individuals. Plasma samples were collected from 29 healthy individuals with normal weight, 17 overweight individuals, and 28 obese individuals who met the inclusion criteria for the study. The plasma samples were analyzed using highly sensitive ultra-high-performance liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry. Results: Pantothenic acid and L-proline showed increased levels in the overweight group, whereas phenylacetaldehyde and glycerophosphocholine were notably decreased compared to the normal weight group. Conversely, the obese group exhibited elevated levels of specific metabolites, including L-leucine, L-tryptophan, phenylalanine, and tyrosine. On the contrary, the obese group demonstrated decreased levels of other metabolites such as 2,3-Diaminopropionic acid, and phenylacetaldehyde. Additionally, significant changes in metabolic pathways, such as pantothenate and CoA biosynthesis, and beta-alanine metabolism, were observed in the overweight group. In contrast, the obese group displayed significant alterations in phenylalanine and tyrosine metabolism, tryptophan metabolism, and beta oxidation of very long-chain fatty acids. Conclusion: The present investigation sheds light on the potential diagnostic significance of certain metabolites in obesity and the impact of their level changes on specific metabolic pathways. Additional studies are necessary to confirm the association of these metabolites in obesity and to confirm their diagnostic value.
Institute
Sharjah Institute for Medical Research
DepartmentResearch institute of medical and health science
LaboratoryBiomarker Discovery Group
Last NameFacility
First NameCore
AddressM32, SIMR, College of Pharmacy, Health Sciences, University of Sharjah, Sharjah, UAE, Sharjah, 000, United Arab Emirates
Emailtims-tof@sharjah.ac.ae
Phone+971 6 5057656
Submit Date2023-12-25
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2024-05-28
Release Version1
Core Facility Core Facility
https://dx.doi.org/10.21228/M8Q72K
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA327891D 26-02-9531Normal Wt
SA327892D 26-01-9530Normal Wt
SA327893D 27-01-9532Normal Wt
SA327894D 28-01-9534Normal Wt
SA327895D 28-02-9535Normal Wt
SA327896D 25-02-9529Normal Wt
SA327897D 27-02-9533Normal Wt
SA327898D 25-01-9528Normal Wt
SA327899D 23-01-9524Normal Wt
SA327900D 22-02-9523Normal Wt
SA327901D 23-02-9525Normal Wt
SA327902D 24-01-9526Normal Wt
SA327903D 24-02-9527Normal Wt
SA327904D 29-01-9536Normal Wt
SA327905D 29-02-9537Normal Wt
SA327906D 60-01-9600Normal Wt
SA327907D 49-02-9579Normal Wt
SA327908D 60-02-9601Normal Wt
SA327909D 67-01-9615Normal Wt
SA327910D 01-01-9479Normal Wt
SA327911D 49-01-9578Normal Wt
SA327912D 45-02-9570Normal Wt
SA327913D 30-02-9539Normal Wt
SA327914D 30-01-9538Normal Wt
SA327915D 40-01-9559Normal Wt
SA327916D 40-02-9560Normal Wt
SA327917D 45-01-9569Normal Wt
SA327918D 22-01-9522Normal Wt
SA327919D 67-02-9616Normal Wt
SA327920D 06-02-9490Normal Wt
SA327921D 06-01-9489Normal Wt
SA327922D 07-01-9491Normal Wt
SA327923D 07-02-9492Normal Wt
SA327924D 09-02-9496Normal Wt
SA327925D 09-01-9495Normal Wt
SA327926D 04-02-9486Normal Wt
SA327927D 04-01-9485Normal Wt
SA327928D 20-02-9519Normal Wt
SA327929D 01-02-9480Normal Wt
SA327930D 02-02-9482Normal Wt
SA327931D 03-01-9483Normal Wt
SA327932D 03-02-9484Normal Wt
SA327933D 10-01-9497Normal Wt
SA327934D 02-01-9481Normal Wt
SA327935D 10-02-9498Normal Wt
SA327936D 16-02-9511Normal Wt
SA327937D 17-02-9513Normal Wt
SA327938D 19-01-9516Normal Wt
SA327939D 20-01-9518Normal Wt
SA327940D 19-02-9517Normal Wt
SA327941D 16-01-9510Normal Wt
SA327942D 17-01-9512Normal Wt
SA327943D 14-02-9506Normal Wt
SA327944D 11-01-9499Normal Wt
SA327945D 12-01-9501Normal Wt
SA327946D 11-02-9500Normal Wt
SA327947D 14-01-9505Normal Wt
SA327948D 12-02-9502Normal Wt
SA327949D 36-01-9551Obese
SA327950D 36-02-9552Obese
SA327951D 37-02-9554Obese
SA327952D 41-01-9561Obese
SA327953D 37-01-9553Obese
SA327954D 78-01-9638Obese
SA327955D 75-02-9633Obese
SA327956D 78-02-9639Obese
SA327957D 75-01-9632Obese
SA327958D 33-01-9545Obese
SA327959D 35-01-9549Obese
SA327960D 33-02-9546Obese
SA327961D 35-02-9550Obese
SA327962D 54-02-9589Obese
SA327963D 56-02-9593Obese
SA327964D 56-01-9592Obese
SA327965D 59-01-9598Obese
SA327966D 59-02-9599Obese
SA327967D 74-01-9630Obese
SA327968D 81-01-9644Obese
SA327969D 55-02-9591Obese
SA327970D 55-01-9590Obese
SA327971D 48-02-9577Obese
SA327972D 48-01-9576Obese
SA327973D 50-01-9580Obese
SA327974D 50-02-9581Obese
SA327975D 54-01-9588Obese
SA327976D 41-02-9562Obese
SA327977D 43-01-9565Obese
SA327978D 62-01-9605Obese
SA327979D 62-02-9606Obese
SA327980D 51-02-9583Obese
SA327981D 51-01-9582Obese
SA327982D 46-02-9573Obese
SA327983D 69-01-9619Obese
SA327984D 69-02-9620Obese
SA327985D 80-02-9643Obese
SA327986D 74-02-9631Obese
SA327987D 80-01-9642Obese
SA327988D 71-02-9625Obese
SA327989D 71-01-9624Obese
SA327990D 46-01-9572Obese
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