Summary of Study ST003361

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002087. The data can be accessed directly via it's Project DOI: 10.21228/M8V825 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003361
Study TitleBile acid–induced gut mitochondrial dysfunction promotes Enterobacteriaceae colonization and associates with dysbiosis in Crohn's disease
Study SummaryHere, we investigated whether bile acids influence gut colonization by Enterobacteriaceae. In an external human dataset, we found association between mucosal Enterobacteriaceae and the expression of mitochondrial damage–related genes. In a murine model, increased intestinal BA availability enhanced colonization by E. coli in an oxygen-dependent manner. Overall, this study establishes BAs as a potential bridge that facilitates interactions between commensals and the host epithelium, laying the essential foundation for future investigations into various intestinal diseases.
Institute
University of British Columbia
Last NameFinlay
First NameBrett
Addressoffice: MSL 333 lab: MSL 363
Emailbfinlay@msl.ubc.ca
Phone604-822-2210
Submit Date2024-07-30
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-08-05
Release Version1
Brett Finlay Brett Finlay
https://dx.doi.org/10.21228/M8V825
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Time point Treatment
SA365865A9Day 0 Chol
SA365866A12Day 0 Chol
SA365867A11Day 0 Chol
SA365868A10Day 0 Chol
SA365869A7Day 0 Chol
SA365870A8Day 0 Chol
SA365871A2Day 0 Con
SA365872A1Day 0 Con
SA365873A6Day 0 Con
SA365874A4Day 0 Con
SA365875A5Day 0 Con
SA365876A3Day 0 Con
SA365877C8Day 14 Chol
SA365878C12Day 14 Chol
SA365879C11Day 14 Chol
SA365880C10Day 14 Chol
SA365881C9Day 14 Chol
SA365882C7Day 14 Chol
SA365883C6Day 14 Con
SA365884C5Day 14 Con
SA365885C4Day 14 Con
SA365886C3Day 14 Con
SA365887C2Day 14 Con
SA365888C1Day 14 Con
SA365889D8Day 21 Chol
SA365890D12Day 21 Chol
SA365891D11Day 21 Chol
SA365892D10Day 21 Chol
SA365893D9Day 21 Chol
SA365894D7Day 21 Chol
SA365895D6Day 21 Con
SA365896D5Day 21 Con
SA365897D4Day 21 Con
SA365898D1Day 21 Con
SA365899D2Day 21 Con
SA365900D3Day 21 Con
SA365901E7Day 28 Chol
SA365902E8Day 28 Chol
SA365903E9Day 28 Chol
SA365904E10Day 28 Chol
SA365905E11Day 28 Chol
SA365906E12Day 28 Chol
SA365907E1Day 28 Con
SA365908E2Day 28 Con
SA365909E3Day 28 Con
SA365910E4Day 28 Con
SA365911E6Day 28 Con
SA365912E5Day 28 Con
Showing results 1 to 48 of 48
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