Summary of Study ST003483

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002139. The data can be accessed directly via it's Project DOI: 10.21228/M84F91 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST003483
Study TitleTissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection (Extracellular data)
Study SummaryInfection is a devastating post-surgical complication, often requiring additional procedures and prolonged antibiotic therapy. This is especially relevant for craniotomy and prosthetic joint infections (PJI), both of which are characterized by biofilm formation on the bone or implant surface, respectively, with S. aureus representing a primary cause. The local tissue microenvironment likely has profound effects on immune attributes that can influence treatment efficacy, which becomes critical to consider when developing therapeutics for biofilm infections. However, the extent to which distinct tissue niches influence immune function during biofilm development remains relatively unknown. To address this, we compare the metabolomic, transcriptomic, and functional attributes of leukocytes in mouse models of S. aureus craniotomy and PJI complemented with patient samples from both infection modalities, which reveals profound tissue niche-dependent differences in nucleic acid, amino acid, and lipid metabolism with links to immune modulation. These signatures are both spatially and temporally distinct, differing not only between infection sites but evolving over time within a single model. Collectively, this demonstrates that biofilms elicit unique immune and metabolic responses that are heavily influenced by the local tissue microenvironment, which will likely have important implications when designing therapeutic approaches targeting these infections. This submission contains the extracellular metabolomic data for the larger project.
Institute
University of Nebraska Medical Center
DepartmentDepartment of pathology, microbiology and immunology
Last NameShinde
First NameDhananjay
AddressDRC 2, 7066, UNMC, Emily st
Emaildhananjay.shinde@unmc.edu
Phone4025597623
Submit Date2024-09-14
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2024-09-24
Release Version1
Dhananjay Shinde Dhananjay Shinde
https://dx.doi.org/10.21228/M84F91
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Experimental Variable
SA383829d14-B5Brain d14
SA383830d14-B4Brain d14
SA383831d14-B3Brain d14
SA383832d14-B2Brain d14
SA383833d14-B1Brain d14
SA383834d3-B2Brain d3
SA383835d3-B1Brain d3
SA383836d3-B3Brain d3
SA383837d3-B5Brain d3
SA383838d3-B4Brain d3
SA383839d7-B3Brain d7
SA383840d7-B1Brain d7
SA383841d7-B2Brain d7
SA383842d7-B4Brain d7
SA383843d7-B5Brain d7
SA383844d14-G5Galea d14
SA383845d14-G4Galea d14
SA383846d14-G3Galea d14
SA383847d14-G2Galea d14
SA383848d14-G1Galea d14
SA383849d3-G1Galea d3
SA383850d3-G4Galea d3
SA383851d3-G3Galea d3
SA383852d3-G5Galea d3
SA383853d3-G2Galea d3
SA383854d7-G4Galea d7
SA383855d7-G5Galea d7
SA383856d7-G3Galea d7
SA383857d7-G2Galea d7
SA383858d7-G1Galea d7
SA383859d14-T2Tissue (PJI) d14
SA383860d14-T5Tissue (PJI) d14
SA383861d14-T4Tissue (PJI) d14
SA383862d14-T3Tissue (PJI) d14
SA383863d14-T1Tissue (PJI) d14
SA383864d3-T4Tissue (PJI) d3
SA383865d3-T5Tissue (PJI) d3
SA383866d3-T3Tissue (PJI) d3
SA383867d3-T2Tissue (PJI) d3
SA383868d3-T1Tissue (PJI) d3
SA383869d7-T2Tissue (PJI) d7
SA383870d7-T4Tissue (PJI) d7
SA383871d7-T1Tissue (PJI) d7
SA383872d7-T5Tissue (PJI) d7
SA383873d7-T3Tissue (PJI) d7
Showing results 1 to 45 of 45
  logo