Summary of Study ST003531
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002173. The data can be accessed directly via it's Project DOI: 10.21228/M8R23J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003531 |
| Study Title | Micropeptide hSPAR, a glutamine regulator, suppresses tumor growth via TRIM21-P27KIP1-mTOR pathway - human MDA-MB-231 breast cancer cell |
| Study Summary | hSPAR, a microprotein, is capable of specifically inhibiting the mTOR signaling activity and cell proliferation in MDA-MB-231 cells. Glutamine, an essential amino acid, plays a crucial role in regulating the mTOR signal. Our data indicate that in MDA-MB-231 cells, overexpressing hSPAR inhibits glutamine uptake, consequently suppressing the activation of the mTOR signaling. |
| Institute | University of Science and Technology of China |
| Last Name | Wang |
| First Name | Wei |
| Address | Division of Life Sciences and Medicine, 443 Huangshan Road, Hefei city, Anhui Province |
| WW571@mail.ustc.edu.cn | |
| Phone | 18604523231 |
| Submit Date | 2024-10-09 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2025-01-06 |
| Release Version | 1 |
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Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Sample source | Transfection |
|---|---|---|---|
| SA387354 | ATG4 | MDA-MB-231 breast cancer cell | ATG |
| SA387355 | ATG5 | MDA-MB-231 breast cancer cell | ATG |
| SA387356 | ATG6 | MDA-MB-231 breast cancer cell | ATG |
| SA387357 | Ctrl4 | MDA-MB-231 breast cancer cell | Ctrl |
| SA387358 | Ctrl5 | MDA-MB-231 breast cancer cell | Ctrl |
| SA387359 | Ctrl6 | MDA-MB-231 breast cancer cell | Ctrl |
| SA387360 | hsPAR4 | MDA-MB-231 breast cancer cell | hsPAR |
| SA387361 | hsPAR5 | MDA-MB-231 breast cancer cell | hsPAR |
| SA387362 | hsPAR6 | MDA-MB-231 breast cancer cell | hsPAR |
| SA387363 | hsPAR_C4 | MDA-MB-231 breast cancer cell | hsPAR_C |
| SA387364 | hsPAR_C5 | MDA-MB-231 breast cancer cell | hsPAR_C |
| SA387365 | hsPAR_C6 | MDA-MB-231 breast cancer cell | hsPAR_C |
| Showing results 1 to 12 of 12 |
