Summary of study ST001437

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000988. The data can be accessed directly via it's Project DOI: 10.21228/M80680 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001437
Study TitleSub-nanoliter metabolomics via mass spectrometry to characterize volume-limited samples - EBC
Study SummaryThe human metabolome provides a window into the mechanisms and biomarkers of various diseases. However, because of limited availability, many sample types are still difficult to study by metabolomic analyses. Here, we present a new mass spectrometry (MS)-based metabolomics strategy that only consumes sub-nanoliter sample volumes. The approach consists of combining a customized metabolomics workflow with a pulsed MS ion generation method, known as triboelectric nanogenerator inductive nanoelectrospray ionization (TENGi nanoESI) MS. The first set of samples tested for this approach included exhaled breath condensates (EBC) collected from cystic fibrosis (CF) patients with impaired glucose tolerance to study the metabolome changes before and after the oral glucose tolerance test.
Institute
Georgia Institute of Technology
Last NameFacundo
First NameFernandez
Address901 Atlantic Dr NW
Emailfernandez@gatech.edu
Phone(404) 385-4432
Submit Date2020-07-29
Raw Data AvailableYes
Raw Data File Type(s).raw
Analysis Type DetailESI
Release Date2020-09-14
Release Version1
Fernandez Facundo Fernandez Facundo
https://dx.doi.org/10.21228/M80680
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN002401
Analysis type MS
Chromatography type None (Direct infusion)
Chromatography system none
Column none
MS Type Other
MS instrument type QTOF
MS instrument name Waters Synapt G2 S QTOF
Ion Mode NEGATIVE
Units Normalized Intensity (Intensity ratio against internal standard signal))

MS:

MS ID:MS002242
Analysis ID:AN002401
Instrument Name:Waters Synapt G2 S QTOF
Instrument Type:QTOF
MS Type:Other
MS Comments:Negative ion mode in the 50-750 m/z range was used for experiments Detailed data process see attached Method file
Ion Mode:NEGATIVE
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