Summary of Study ST001855

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001170. The data can be accessed directly via it's Project DOI: 10.21228/M8G98C This work is supported by NIH grant, U2C- DK119886.

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Study IDST001855
Study TitleThe metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 1)
Study SummaryC57BL/6 mice were anesthetized using isoflurane. UIR was induced by clamping the right renal pedicle for 45 minutes and then releasing it to allow reperfusion, leaving the left kidney intact. Sham treated mice served as controls. Each mouse was located supine on a thermostatic pad (37 °C) to maintain its body temperature throughout the whole process. After 3 days of recovery, the mice received a daily intraperitoneal (i.p.) injection of FG4592 (10 mg/kg) or vehicle for 18 consecutive days. After treatment, the mice were sacrificed. Non-target metabolomics analysis was carried out using the kidney tissues of mice sacrificed at day 21 after UIR.
Institute
Children's Hospital of Nanjing Medical University
Last NameChen
First NameWeiyi
Address72 Guangzhou Road, Nanjing 210008, P. R. of China
Emailchen.weiyi@qq.com
Phone0086-25-8311-7309
Submit Date2021-06-30
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-07-07
Release Version1
Weiyi Chen Weiyi Chen
https://dx.doi.org/10.21228/M8G98C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN003006 AN003007
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Thermo Ultimate 3000 system Thermo Ultimate 3000 system
Column Waters ACQUITY UPLC HSS T3 Waters ACQUITY UPLC HSS T3
MS Type ESI ESI
MS instrument type Orbitrap Orbitrap
MS instrument name Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap
Ion Mode POSITIVE NEGATIVE
Units AUC AUC

MS:

MS ID:MS002795
Analysis ID:AN003006
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Proteowizard software (v3.0.8789)
Ion Mode:POSITIVE
  
MS ID:MS002796
Analysis ID:AN003007
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Proteowizard software (v3.0.8789)
Ion Mode:NEGATIVE
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