Summary of Study ST002194

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001398. The data can be accessed directly via it's Project DOI: 10.21228/M8141Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002194
Study TitleMetabolic profiling at COVID-19 onset shows disease severity and sex-specific dysregulation
Study SummaryIn this study CE-MS and GC-MS based metabolomics was used to analyze COVID-19 disease. In total, 144 individuals classified as healthy, asymptomatic/mils, moderate and severe according to the highest COVID-19 severity status, were analyzed.
Institute
CEMBIO
Last NameBarbas
First NameCoral
AddressCEU Universities, Urbanización Montepríncipe
Emailcbarbas@ceu.es
Phone+34 913724700
Submit Date2022-06-09
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailGC/LC-MS
Release Date2022-06-17
Release Version1
Coral Barbas Coral Barbas
https://dx.doi.org/10.21228/M8141Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN003591 AN003592
Analysis type MS MS
Chromatography type Other GC
Chromatography system Agilent 7100 CE 8890
Column silica capillary (100 cm; inner diameter, 50 µm, Agilent Technologies) Agilent DB5-MS (30m x 0.25mm, 0.25um)
MS Type ESI EI
MS instrument type TOF Single quadrupole
MS instrument name Agilent CE-TOFMS Agilent 5977B
Ion Mode POSITIVE UNSPECIFIED
Units Peak Area Corrected areas

MS:

MS ID:MS003346
Analysis ID:AN003591
Instrument Name:Agilent CE-TOFMS
Instrument Type:TOF
MS Type:ESI
MS Comments:Data were acquired in positive ionization polarity with a full scan range from 70 to 1000 m/z at a rate of 1.36 scan/s. The rest of MS conditions were: fragmentor set to 125 V, skimmer to 65 V, OCT RF Vpp to 750 V, drying gas temperature to 200 °C, flow rate to 10 L/min, nebulizer to 10 psig, and capillary voltage to 3500 V. The sheath liquid used for detection contained two reference masses (5 µL of purine with m/z 121.0509 and 5 µL of HP-0921 with m/z 922.0098) in MeOH/water (1/1; v/v) with 1 mM formic acid and the flow rate was set to 0.6 mL/min (split 1:100). The data acquisition was made using the Agilent MassHunter Workstation (Agilent Technologies).
Ion Mode:POSITIVE
Analysis Protocol File:Sample_Analysis.pdf
  
MS ID:MS003347
Analysis ID:AN003592
Instrument Name:Agilent 5977B
Instrument Type:Single quadrupole
MS Type:EI
MS Comments:The transfer line temperature was stablished at 280 °C and the electron ionization (EI) source was operated at 70 eV and the filament source temperature was set at 200 °C. Mass spectra were collected over a mass range of 50 - 600 m/z at a scan rate of 2.7 scans/s. Data were acquired using the Agilent MassHunter Workstation GC/MS Data Acquisition (version 10.0).
Ion Mode:UNSPECIFIED
Analysis Protocol File:Sample_Analysis.pdf
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