Summary of Study ST004042

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002534. The data can be accessed directly via it's Project DOI: 10.21228/M83G11 This work is supported by NIH grant, U2C- DK119886.

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Study IDST004042
Study TitleUntargeted Metabolomics Identifies Oncometabolites Induced by P2-HNF4α Overexpression in Hepatocytes
Study SummaryThis study explores the metabolic impact of P2-HNF4α overexpression in primary mouse hepatocytes. Using untargeted metabolomics, we compared metabolite profiles between control and P2-HNF4α-overexpressing cells to identify metabolic pathways potentially altered in liver disease and HCC.
Institute
University of Tennessee Health Science Center
DepartmentIMM
LaboratoryMahan Lab
Last NameFekry
First NameBaharan
Address1825 Pressler St, Houston TX 77030. USA.
EmailBaharan.Fekry@uth.tmc.edu
Phone18434693199
Submit Date2025-07-03
Analysis Type DetailLC-MS
Release Date2025-08-05
Release Version1
Baharan Fekry Baharan Fekry
https://dx.doi.org/10.21228/M83G11
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN006681
Chromatography ID CH005077
MS ID MS006380
Analysis type MS
Chromatography type Reversed phase
Chromatography system Agilent 1200 Series HPLC coupled to Agilent 6538 UHD Accurate-Mass Q-TOF
Column Agilent ZORBAX Extend-C18 Rapid Resolution HT (2.1 × 50 mm, 1.8 µm)
MS Type ESI
MS instrument type QTOF
MS instrument name Agilent 6538 QTOF
Ion Mode POSITIVE
Units LC/MS Peak intensity

MS:

MS ID:MS006380
Analysis ID:AN006681
Instrument Name:Agilent 6538 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:MS1 spectra were acquired over a mass range of 100–2000 m/z using electrospray ionization (ESI) in positive mode. Acquisition was performed under the following conditions: capillary voltage of 3.5 kV, drying gas flow rate of 5 L/min, nebulizer pressure of 5 psi, and source temperature of 300°C.
Ion Mode:POSITIVE
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