Summary of Study ST000903

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000627. The data can be accessed directly via it's Project DOI: 10.21228/M8MT2H This work is supported by NIH grant, U2C- DK119886.


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Study IDST000903
Study TitlePharmacometabolomic analysis of rat hippocampus and plasma in response to chronic stress and albiflorin treament
Study TypeAnimal study
Study SummaryMale Sprague-Dawley (SD) rats were exposed to one random stressor per day for 35 d. Following four weeks of stress exposure, rats with stress-induced depression-like behaviors were treated daily with either saline, fluoxetine or albiflorin for 7 days via intragastric gavage. Rat heparinized plasma was collected after drug treatment. After behavior tests, rats were sacrificed and the hippocampus was collected. Pharmacometabolomic analysis was conducted for both plasma and hippocampal samples
Beijing Wonner Biotech. Ltd. Co.
Last NameZhang
First NameZuoguang
AddressNo.9, Kexing Road, Fengtai, Beijing, Beijing, 101111, China
Submit Date2017-11-16
Num Groups4
Study CommentsAnimal study
Analysis Type DetailLC-MS
Release Date2018-02-07
Release Version1
Zuoguang Zhang Zuoguang Zhang application/zip

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Project ID:PR000627
Project DOI:doi: 10.21228/M8MT2H
Project Title:Metabolomic changes of chronic stressed rats in response to albiflorin treatment
Project Summary:Depression is a complex and multifactorial disorder with various co-morbid symptoms. Current pharmacotherapies are limited by slow onset, low efficacy, and distressing side effects. Natural products are a robust source of new drugs. To understand the mechanisms of action of albiflorin, we examined the changes in global patterns of metabolism in the hippocampus and plasma of chronic stressed rats after albiflorin treatment using metabolomics
Institute:Beijing Wonner Biotech. Ltd. Co.
Last Name:Zhang
First Name:Zuoguang
Address:No.9, Kexing Road, Fengtai, Beijing, Beijing, 101111, China