Summary of Study ST000903
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000627. The data can be accessed directly via it's Project DOI: 10.21228/M8MT2H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000903 |
| Study Title | Pharmacometabolomic analysis of rat hippocampus and plasma in response to chronic stress and albiflorin treament |
| Study Type | Animal study |
| Study Summary | Male Sprague-Dawley (SD) rats were exposed to one random stressor per day for 35 d. Following four weeks of stress exposure, rats with stress-induced depression-like behaviors were treated daily with either saline, fluoxetine or albiflorin for 7 days via intragastric gavage. Rat heparinized plasma was collected after drug treatment. After behavior tests, rats were sacrificed and the hippocampus was collected. Pharmacometabolomic analysis was conducted for both plasma and hippocampal samples |
| Institute | Beijing Wonner Biotech. Ltd. Co. |
| Last Name | Zhang |
| First Name | Zuoguang |
| Address | No.9, Kexing Road, Fengtai, Beijing, Beijing, 101111, China |
| leekefeng@hotmail.com | |
| Phone | 86-10-65670787 |
| Submit Date | 2017-11-16 |
| Num Groups | 4 |
| Study Comments | Animal study |
| Analysis Type Detail | LC-MS |
| Release Date | 2018-02-07 |
| Release Version | 1 |
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Project:
| Project ID: | PR000627 |
| Project DOI: | doi: 10.21228/M8MT2H |
| Project Title: | Metabolomic changes of chronic stressed rats in response to albiflorin treatment |
| Project Summary: | Depression is a complex and multifactorial disorder with various co-morbid symptoms. Current pharmacotherapies are limited by slow onset, low efficacy, and distressing side effects. Natural products are a robust source of new drugs. To understand the mechanisms of action of albiflorin, we examined the changes in global patterns of metabolism in the hippocampus and plasma of chronic stressed rats after albiflorin treatment using metabolomics |
| Institute: | Beijing Wonner Biotech. Ltd. Co. |
| Last Name: | Zhang |
| First Name: | Zuoguang |
| Address: | No.9, Kexing Road, Fengtai, Beijing, Beijing, 101111, China |
| Email: | leekefeng@hotmail.com |
| Phone: | 86-10-65670787 |
