Summary of Study ST001212
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000823. The data can be accessed directly via it's Project DOI: 10.21228/M89D5Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001212 |
Study Title | Fish-oil supplementation in pregnancy, child metabolomics and asthma risk |
Study Summary | We investigated potential metabolic mechanisms using untargeted liquid chromatography-mass spectrometry-based metabolomics on 577 plasma samples collected at age 6 months in the offspring of mothers participating in the n-3 LCPUFA randomized controlled trial. First, associations between the n-3 LCPUFA supplementation groups and child metabolite levels were investigated using univariate regression models and data-driven partial least square discriminant analyses (PLS-DA). Second, we analyzed the association between the n-3 LCPUFA metabolomic profile and asthma development using Cox-regression. Third, we conducted mediation analyses to investigate whether the protective effect of n-3 LCPUFA on asthma was mediated via the metabolome |
Institute | University of Copenhagen |
Department | Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital |
Last Name | Rago |
First Name | Daniela |
Address | Ledreborg Alle 34, DK-2820 Gentofte; Denmark |
daniela.rago@dbac.dk | |
Phone | (+45) 39777360 |
Submit Date | 2019-07-10 |
Analysis Type Detail | LC-MS |
Release Date | 2019-09-23 |
Release Version | 1 |
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Project:
Project ID: | PR000823 |
Project DOI: | doi: 10.21228/M89D5Q |
Project Title: | Fish-oil supplementation in pregnancy, child metabolomics and asthma risk |
Project Type: | Untargeted metabolomics |
Project Summary: | We investigated potential metabolic mechanisms using untargeted liquid chromatography-mass spectrometry-based metabolomics on 577 plasma samples collected at age 6 months in the offspring of mothers participating in the n-3 LCPUFA randomised controlled trial. First, associations between the n-3 LCPUFA supplementation groups and child metabolite levels were investigated using univariate regression models and data-driven partial least square discriminant analyses (PLS-DA). Second, we analysed the association between the n-3 LCPUFA metabolomic profile and asthma development using Cox-regression. Third, we conducted mediation analyses to investigate whether the protective effect of n-3 LCPUFA on asthma was mediated via the metabolome. |
Institute: | University of Copenhagen |
Department: | Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital |
Last Name: | Rago |
First Name: | Daniela |
Address: | Ledreborg Alle 34, Gentofte, DK, 2820, Denmark |
Email: | daniela.rago@dbac.dk |
Phone: | +45-39777360 |