Summary of Study ST001212

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000823. The data can be accessed directly via it's Project DOI: 10.21228/M89D5Q This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001212
Study TitleFish-oil supplementation in pregnancy, child metabolomics and asthma risk
Study SummaryWe investigated potential metabolic mechanisms using untargeted liquid chromatography-mass spectrometry-based metabolomics on 577 plasma samples collected at age 6 months in the offspring of mothers participating in the n-3 LCPUFA randomized controlled trial. First, associations between the n-3 LCPUFA supplementation groups and child metabolite levels were investigated using univariate regression models and data-driven partial least square discriminant analyses (PLS-DA). Second, we analyzed the association between the n-3 LCPUFA metabolomic profile and asthma development using Cox-regression. Third, we conducted mediation analyses to investigate whether the protective effect of n-3 LCPUFA on asthma was mediated via the metabolome
Institute
University of Copenhagen
DepartmentCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital
Last NameRago
First NameDaniela
AddressLedreborg Alle 34, DK-2820 Gentofte; Denmark
Emaildaniela.rago@dbac.dk
Phone(+45) 39777360
Submit Date2019-07-10
Analysis Type DetailLC-MS
Release Date2019-09-23
Release Version1
Daniela Rago Daniela Rago
https://dx.doi.org/10.21228/M89D5Q
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000823
Project DOI:doi: 10.21228/M89D5Q
Project Title:Fish-oil supplementation in pregnancy, child metabolomics and asthma risk
Project Type:Untargeted metabolomics
Project Summary:We investigated potential metabolic mechanisms using untargeted liquid chromatography-mass spectrometry-based metabolomics on 577 plasma samples collected at age 6 months in the offspring of mothers participating in the n-3 LCPUFA randomised controlled trial. First, associations between the n-3 LCPUFA supplementation groups and child metabolite levels were investigated using univariate regression models and data-driven partial least square discriminant analyses (PLS-DA). Second, we analysed the association between the n-3 LCPUFA metabolomic profile and asthma development using Cox-regression. Third, we conducted mediation analyses to investigate whether the protective effect of n-3 LCPUFA on asthma was mediated via the metabolome.
Institute:University of Copenhagen
Department:Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital
Last Name:Rago
First Name:Daniela
Address:Ledreborg Alle 34, Gentofte, DK, 2820, Denmark
Email:daniela.rago@dbac.dk
Phone:+45-39777360
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