Summary of Study ST001301
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000882. The data can be accessed directly via it's Project DOI: 10.21228/M8PD88 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001301 |
| Study Title | Luminal metabolome profiles of human microbiota-associated (HMA) mice treated with anti-IL-22 antibody or control antibody |
| Study Summary | Luminal (fecal) metabolome of anti-IL-22 antibody-treated HMA mice and control antibody-treated HMA mice were compared. |
| Institute | University of Michigan |
| Department | Internal Medicine |
| Last Name | Kamada |
| First Name | Nobuhiko |
| Address | 1150 W Medical center Dr, Ann Arbor, MI 48109, USA |
| nkamada@umich.edu | |
| Phone | +1-734-763-2142 |
| Submit Date | 2019-12-22 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2020-01-08 |
| Release Version | 1 |
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Project:
| Project ID: | PR000882 |
| Project DOI: | doi: 10.21228/M8PD88 |
| Project Title: | Luminal metabolome profiles of human microbiota-associated (HMA) mice treated with anti-IL-22 antibody or control antibody |
| Project Summary: | We found that healthy (HC)-HMA mice, GF mice were colonized with gut microbiota derived from human HC, were protected from Clostridioides difficile (C. difficile) infection. However, the colonization resistance of HC-HMA mice was abolished by treatment of anti-IL-22 antibody, unlike control antibody-treated HC-HMA mice. Additionally, the gut microbial composition of anti-IL22 antibody-treated HC-HMA mice, C. difficile-susceptible mice, were differ from that of control antibody, thereby it appears that luminal metabolome is changed between 2 groups. To examine the change in the luminal metabolites, fecal samples were collected from anti-IL-22 /control -antibody treated HC-HMA mice, and metabolite profiles of them were analyzed. |
| Institute: | University of Michigan |
| Department: | Internal Medicine |
| Last Name: | Kamada |
| First Name: | Nobuhiko |
| Address: | 1150 W Medical center Dr, Ann Arbor, MI 48109, USA |
| Email: | nkamada@umich.edu |
| Phone: | +1-734-763-2142 |
