Summary of Study ST002089
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000907. The data can be accessed directly via it's Project DOI: 10.21228/M8FQ2X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST002089 |
| Study Title | Plasma metabolomic signatures of COPD: A metabolomic severity score for airflow obstruction and emphysema. |
| Study Type | MS qualitative analysis |
| Study Summary | The NIH sponsored multicenter Genetic Epidemiology of COPD (COPDGene (ClinicalTrials.gov Identifier: NCT01969344) study was approved and reviewed by the institutional review board at all participating centers (1). All study participants provided written informed consent. This study enrolled 10,198 non-Hispanic white (NHW) and African American (AA) individuals from January 2008 until April 2011 (Phase 1) who were aged 45-80 with ≥10 pack-year smoking history and no exacerbations for >30 days. In addition, 465 age and gender matched healthy individuals with no history of smoking were enrolled as controls (mostly at Phase 2). From July 2013 to July 2017, 5,697 subjects returned for an in-person 5-year visit. Each in-person visit included spirometry before and after albuterol, quantitative CT imaging of the chest, and blood sampling. From two clinical centers (National Jewish Health and University of Iowa) 1,136 subjects (1,040 NHW, 96 AA) participated in an ancillary study in which they provided fresh frozen plasma collected using an 8.5 ml p100 tube (Becton Dickinson) at Phase 2. This study is a duplicate of ST001443 (https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST001443&StudyType=MS&ResultType=5) but differs in analysis and contains batch normalized data using median metabolite values. |
| Institute | National Jewish Health |
| Department | Division of Pulmonary Medicine |
| Laboratory | Bowler |
| Last Name | Bowler |
| First Name | Russell |
| Address | 1400 Jackson St. Denver, CO 80206 |
| bowlerr@njhealth.org | |
| Phone | 303 270 2014 |
| Submit Date | 2022-02-08 |
| Total Subjects | 1120 |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-03-09 |
| Release Version | 1 |
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Project:
| Project ID: | PR000907 |
| Project DOI: | doi: 10.21228/M8FQ2X |
| Project Title: | Plasma metabolomic signatures of COPD |
| Institute: | National Jewish Health |
| Department: | Division of Pulmonary Medicine |
| Last Name: | Bowler |
| First Name: | Russell |
| Address: | 1400 Jackson St. Denver, CO 80206 |
| Email: | bowlerr@njhealth.org |
| Phone: | 303 270 2014 |
| Funding Source: | NHLBI R21 HL140376, R01HL129937, R01HL 095432, R01 HL089856, R01 HL089897); and UL1 RR025680 from NCRR/HIH |
