Summary of Study ST002124
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001348. The data can be accessed directly via it's Project DOI: 10.21228/M8GD8D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002124 |
| Study Title | Amino acids and TCA substrates in hematopoietic cells (Part1) |
| Study Summary | This study uses [13C,15N] labeled amino acids to study the amino acid consumption and their catabolism into tricarboxylic acid cycle substrates in hematopoietic stem cells, hemopoietic progenitors, and differentiated hematopoietic cells under different conditions, such as homeostasis and proliferation and with drug treatment. |
| Institute | Sun Yat-sen University |
| Last Name | Zhao |
| First Name | Meng |
| Address | Zhongshan 2nd Road |
| zhaom38@mail.sysu.edu.cn | |
| Phone | 18138799889 |
| Submit Date | 2022-04-06 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | cdf |
| Analysis Type Detail | GC-MS |
| Release Date | 2022-11-01 |
| Release Version | 1 |
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Project:
| Project ID: | PR001348 |
| Project DOI: | doi: 10.21228/M8GD8D |
| Project Title: | Amino acid catabolism in hematopoietic cells |
| Project Summary: | Hematopoietic stem cells (HSCs) adapt their metabolism to maintenance and proliferation, but the mechanism remains incompletely understood. Here, we have investigated the total levels, uptake and catabolism of amino acid in hematopoietic stem cells, hemopoietic progenitors, and differentiated hematopoietic cells. We have also studied the catabolism of amino acid in hematopoietic stem cells under different conditions, such as homeostasis and proliferation and with drug treatment. Moreover, glycolytic metabolite, NAD+ precursor nicotinamide riboside (NR), accelerated AA catabolism to activate GCN2 and sustain long-term function of HSCs. Overall, our study uncovers the direct links between metabolic alterations and translation control in HSCs during homeostasis and proliferation. |
| Institute: | Sun Yat-sen University |
| Last Name: | Zhao |
| First Name: | Meng |
| Address: | Zhongshan 2nd Road |
| Email: | zhaom38@mail.sysu.edu.cn |
| Phone: | 18138799889 |
