Summary of Study ST002211

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001412. The data can be accessed directly via it's Project DOI: 10.21228/M86M67 This work is supported by NIH grant, U2C- DK119886.

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Study IDST002211
Study TitleEffects of Medwakh Smoking on Oxidative Stress and Inflammation Among Youth in UAE using Liquid chromatography-mass spectrometry
Study SummaryOxidative stress and inflammation are closely related, and inter-dependent pathophysiological processes. Oxidative stress plays a key role in the pathophysiology of several chronic inflammatory conditions that causes cellular alterations such as lipid damage, increase of cell permeability, apoptosis/cell death, alteration in growth factors, and signaling pathways.An imbalance between the production of reactive oxygen species (ROS) and their neutralization by the antioxidant system results in the onset of oxidative stress which subsequently leads to the release of chronic inflammatory mediators such as pro-inflammatory cytokines, which causes damages to DNA, proteins, and lipids.LC-MSMS is widely used for non-targeted and non-invasive metabolomics of biological samples including saliva in a variety of conditions such as inflammatory conditions, cancers, diabetes, etc. However, to the best of our knowledge, there are currently no metabolomics-based studies identifying salivary biomarkers associated with inflammation and oxidative stress utilizing HPLC-ESI-QTOF-MS. Therefore, in this study, we aim to discover the biochemical and physiological changes induced by medwak smoking and explore the metabolomics profile of medwak smokers with a focus on the markers of oxidative stress and inflammation in comparison to nonsmokers.
Institute
Sharjah Institute for Medical Research
DepartmentWound Healing and Oral Diagnostics
LaboratorySharjah Institute for Medical Research
Last NameK.G
First NameAghila Rani
AddressSharjah, UAE
Emailanair@sharjah.ac.ae
Phone0562206252
Submit Date2022-06-20
Num Groups2
Total Subjects60
Num Males60
Study CommentsNA
PublicationsNA
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2024-01-01
Release Version1
Aghila Rani K.G Aghila Rani K.G
https://dx.doi.org/10.21228/M86M67
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001412
Project DOI:doi: 10.21228/M86M67
Project Title:Effects of Medwakh Smoking on Oxidative Stress and Inflammation Among Youth in UAE using Liquid chromatography-mass spectrometry
Project Type:Untargeted metabolomics
Project Summary:The use of alternative tobacco products is rampant among the youth in the Middle East and currently spreading worldwide. It is speculated that public policies that have proven effective in limiting cigarette usage and facilitating cessation of its use resulted in the widespread use of alternative tobacco products (ATPs) as major forms of tobacco delivery systems. Previous studies have reported the acute effects of smoking medwak on altering the systolic blood pressure, cardiovascular and respiratory systems. Smoking medwakh results in the release of a mixture of toxic chemicals including nicotine, carbon monoxide, and oxidizing gases 8-10. Inhalation of these toxic gases results in triggering of oxidative stress pathways that leads to endothelial dysfunction, inflammation, and platelet activation 11,12. Therefore, in this study, we aim to discover the biochemical and physiological changes induced by medwak smoking and explore the metabolomics profile of medwak smokers with a focus on the markers of oxidative stress and inflammation in comparison to nonsmokers.
Institute:University of Sharjah
Department:Wound Healing and Oral Diagnostics
Laboratory:Sharjah Institute for Medical Research
Last Name:K.G
First Name:Aghila Rani
Address:Sharjah, UAE
Email:anair@sharjah.ac.ae
Phone:0562206252
Funding Source:Al Jalila
Project Comments:NA
Publications:NA
Contributors:NA
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