Summary of Study ST002991
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001862. The data can be accessed directly via it's Project DOI: 10.21228/M81M8F This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002991 |
| Study Title | Metabolomics studies on human colorectal cancer cell lines |
| Study Summary | Although targeting oxidative phosphorylation (OXPHOS) for cancer treatment is currently impeded due to dose-limiting toxicities, there remain opportunities through combinations that provide therapeutic benefits at doses attainable in patients. On the other hand, while glycolysis-deficient cancers are generally vulnerable to OXPHOS inhibition in preclinical models, the full extent of phenotypical and mechanistic consequences of inhibiting OXPHOS in cancers capable of glycolysis is not yet well understood. We aimed to clarify the response and underlying mechanisms of colorectal cancer (CRC) that commonly exhibit the glycolytic phenotype to OXPHOS inhibition and to identify potential approaches to render such cells more sensitive to OXPHOS inhibitors. The responses of glycolysis-competent CRC cells to targeting OXPHOS were tested using targeted meatbolomics. |
| Institute | University of Newcastle |
| Last Name | Zhao |
| First Name | Xiaohong |
| Address | University Drive, Callaghan, NSW, 2308, Australia |
| xiaohong.zhao@newcastle.edu.au | |
| Phone | 61 0466219528 |
| Submit Date | 2023-11-27 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2025-01-13 |
| Release Version | 1 |
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Project:
| Project ID: | PR001862 |
| Project DOI: | doi: 10.21228/M81M8F |
| Project Title: | DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer |
| Project Summary: | Although targeting oxidative phosphorylation (OXPHOS) for cancer treatment is currently impeded due to dose-limiting toxicities, there remain opportunities through combinations that provide therapeutic benefits at doses attainable in patients. On the other hand, while glycolysis-deficient cancers are generally vulnerable to OXPHOS inhibition in preclinical models, the full extent of phenotypical and mechanistic consequences of inhibiting OXPHOS in cancers capable of glycolysis is not yet well understood. We aimed to clarify the response and underlying mechanisms of colorectal cancer (CRC) that commonly exhibit the glycolytic phenotype to OXPHOS inhibition and to identify potential approaches to render such cells more sensitive to OXPHOS inhibitors. |
| Institute: | The University of Newcastle |
| Last Name: | Zhao |
| First Name: | Xiaohong |
| Address: | University Drive, Callaghan, NSW, 2308, Australia |
| Email: | xiaohong.zhao@newcastle.edu.au |
| Phone: | 61 0466219528 |
