Summary of Study ST003361
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002087. The data can be accessed directly via it's Project DOI: 10.21228/M8V825 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003361 |
| Study Title | Bile acid–induced gut mitochondrial dysfunction promotes Enterobacteriaceae colonization and associates with dysbiosis in Crohn's disease |
| Study Summary | Here, we investigated whether bile acids influence gut colonization by Enterobacteriaceae. In an external human dataset, we found association between mucosal Enterobacteriaceae and the expression of mitochondrial damage–related genes. In a murine model, increased intestinal BA availability enhanced colonization by E. coli in an oxygen-dependent manner. Overall, this study establishes BAs as a potential bridge that facilitates interactions between commensals and the host epithelium, laying the essential foundation for future investigations into various intestinal diseases. |
| Institute | University of British Columbia |
| Last Name | Finlay |
| First Name | Brett |
| Address | office: MSL 333 lab: MSL 363 |
| bfinlay@msl.ubc.ca | |
| Phone | 604-822-2210 |
| Submit Date | 2024-07-30 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-08-05 |
| Release Version | 1 |
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Project:
| Project ID: | PR002087 |
| Project DOI: | doi: 10.21228/M8V825 |
| Project Title: | Bile acid–induced gut mitochondrial dysfunction promotes Enterobacteriaceae colonization and associates with dysbiosis in Crohn's disease |
| Project Summary: | Members of the Enterobacteriaceae family of bacteria are often overrepresented in inflammatory bowel disease (IBD). Bile acids (BAs) are cholesterol derivatives that are known to affect the growth of potentially pathogenic commensals (pathobionts), including those from the Enterobacteriaceae family. Furthermore, BAs are often increased in the colonic lumen of IBD patients, including patients with Crohn’s disease (CD). Here, we investigated whether bile acids influence gut colonization by Enterobacteriaceae. |
| Institute: | University of British Columbia |
| Last Name: | Finlay |
| First Name: | Brett |
| Address: | office: MSL 333 lab: MSL 363 |
| Email: | bfinlay@interchange.ubc.ca |
| Phone: | 604-822-2210 |
| Funding Source: | Canadian Institutes of Health Research (CIHR) [FDN-159935] and Genome Canada/Genome BC (264PRO) |
