Summary of Study ST004042
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002534. The data can be accessed directly via it's Project DOI: 10.21228/M83G11 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST004042 |
| Study Title | Untargeted Metabolomics Identifies Oncometabolites Induced by P2-HNF4α Overexpression in Hepatocytes |
| Study Summary | This study explores the metabolic impact of P2-HNF4α overexpression in primary mouse hepatocytes. Using untargeted metabolomics, we compared metabolite profiles between control and P2-HNF4α-overexpressing cells to identify metabolic pathways potentially altered in liver disease and HCC. |
| Institute | University of Tennessee Health Science Center |
| Department | IMM |
| Laboratory | Mahan Lab |
| Last Name | Fekry |
| First Name | Baharan |
| Address | 1825 Pressler St, Houston TX 77030. USA. |
| Baharan.Fekry@uth.tmc.edu | |
| Phone | 18434693199 |
| Submit Date | 2025-07-03 |
| Analysis Type Detail | LC-MS |
| Release Date | 2025-08-05 |
| Release Version | 1 |
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Project:
| Project ID: | PR002534 |
| Project DOI: | doi: 10.21228/M83G11 |
| Project Title: | Untargeted metabolomics analysis on mouse hepatocytes |
| Project Summary: | To determine whether specific metabolites are associated with the induction of P2-HNF4α in liver disease and hepatocellular carcinoma (HCC), we performed untargeted metabolomics on hepatocytes isolated from wild-type mouse liver, which predominantly express the tumor-suppressive P1-HNF4α isoform. Using lentiviral transduction, we overexpressed the P2-HNF4α isoform and conducted metabolite profiling on cell lysates from both control and P2-HNF4α-overexpressing cells. Data analysis was performed using MetaboAnalyst (v5.0), resulting in a list of approximately 120 matched compounds representing significantly predicted metabolites. This study aims to uncover metabolic signatures associated with P2-HNF4α expression, offering insights into its potential role in liver pathogenesis and tumor progression. |
| Institute: | University of Texas Health Science Center at Houston |
| Department: | IMM |
| Laboratory: | Mahan Lab |
| Last Name: | Fekry |
| First Name: | Baharan |
| Address: | 1825 Pressler St, Houston TX 77030. USA, |
| Email: | Baharan.Fekry@uth.tmc.edu |
| Phone: | 7135002487 |
