Summary of Study ST000337
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000269. The data can be accessed directly via it's Project DOI: 10.21228/M81307 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000337 |
| Study Title | Metabolomics Approach to Allograft Assessment in Liver Transplantation |
| Study Type | Retrospective analysis of biobanked liver tissue from organ donors |
| Study Summary | This pilot study is designed to apply several types of metabolomic analysis for liver allograft assessment with the aim of identifying candidate biomarkers for allograft function and to develop a methodology that could be applied to larger scale studies. The three main categories of metabolomic analysis are reflected in each of the specific aims, including a targeted profiling of central carbon metabolism, open lipidomic and metabolomic profiling for hypothesis generation and MALDI-IMS for tissue-based spatial analysis. Each of these approaches offers potential benefits that could be optimized in a protocol for larger scale studies depending the results of the pilot investigations. |
| Institute | Ochsner Multi-Organ Transplant Institute |
| Department | SECIM |
| Laboratory | Abdominal Organ Transplantation |
| Last Name | Seal |
| First Name | John |
| Address | 1514 Jefferson Highway, New Orleans, LA 70121 |
| John.Seal@ochsner.org | |
| Phone | 504-232-4253 |
| Submit Date | 2016-01-17 |
| Num Groups | 3 |
| Total Subjects | Targeted analysis and open profiling: Control group - standard criteria donor (N=15); Experimental group - donation-after-cardiac-death donors (N=10). MALDI-IMS - standard criteria donor (N=10) |
| Raw Data File Type(s) | raw(Thermo), d |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-01-17 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Sample Preparation:
| Sampleprep ID: | SP001183 |
| Sampleprep Summary: | Amino acid assay|CoA assay|NAD-ATP assay|NADH assay|Organic acid assay |
| Sampleprep Protocol Filename: | SB_AA_Assay.pdf SB_CoA_Assay.pdf SB_NAD-ATP_Assay_Agilent.pdf SB_NADH_Assay_Agilent.pdf SB_OA_Assay.pdf |
