Summary of Study ST001273

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000859. The data can be accessed directly via it's Project DOI: 10.21228/M8NH5V This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001273
Study TitleLipidomics Dataset of Sonication-Induced Traumatic Optic Neuropathy in Mice
Study SummaryTraumatic optic neuropathy (TON) is the loss of vision secondary to trauma. Approximately two weeks after traumatic damage, diffuse retinal ganglion cell loss and axon degeneration of the optic nerve are exhibited. Here we present the changes that occur in the optic nerve lipidome of two-month-old C57BL/6J mice following sonication-induced TON (SI-TON), which closely models the indirect clinical mechanism in TON. Optic nerves were harvested at three time points following injury: 1-day, 7-days, and 14-days for comparison with the control group (uninjured optic nerves from 2-month-old mice). Lipidomic changes were observed at each of the various time points, with a pattern of progression present in multiple lipid classes. This data demonstrates the distinct lipidomic changes at each time point following indirect trauma to the optic nerve.
Institute
University of Miami
DepartmentOphthalmology, Bascom Palmer Eye Institute
Last NameBhattacharya
First NameSanjoy
Address1638 NW 10th Avenue, Suite 707A University of Miami Miami, FL, 33136
EmailSBhattacharya@med.miami.edu
Phone305-482-4103
Submit Date2019-06-10
Num Groups4
Total Subjects31
Num Males15
Num Females16
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2019-11-20
Release Version1
Sanjoy Bhattacharya Sanjoy Bhattacharya
https://dx.doi.org/10.21228/M8NH5V
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Sample Preparation:

Sampleprep ID:SP001353
Sampleprep Summary:As described in collection
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