Summary of Study ST001856

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001170. The data can be accessed directly via it's Project DOI: 10.21228/M8G98C This work is supported by NIH grant, U2C- DK119886.


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Study IDST001856
Study TitleThe metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 2)
Study SummaryC57BL/6 mice were anesthetized using isoflurane. UIR was induced by clamping the right renal pedicle for 45 minutes and then releasing it to allow reperfusion, leaving the left kidney intact. Sham treated mice served as controls. Each mouse was located supine on a thermostatic pad (37 °C) to maintain its body temperature throughout the whole process. After 3 days of recovery, the mice received a daily intraperitoneal (i.p.) injection of FG4592 (10 mg/kg) or vehicle for 7 consecutive days. After treatment, the mice were sacrificed.Non-target metabolomics analysis was carried out using the kidney tissues of mice sacrificed at day 10 after UIR.
Children's Hospital of Nanjing Medical University
Last NameWeiyi
First NameChen
Address72 Guangzhou Road, Nanjing 210008, P. R. of China
Submit Date2021-07-01
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-07-07
Release Version1
Chen Weiyi Chen Weiyi application/zip

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Sample Preparation:

Sampleprep ID:SP001939
Sampleprep Summary:20 mg of each tissue sample were homogenized with 0.6 mL of 2 chlorophenylalanine (4 ppm) containing methanol (−20 °C), centrifuged, and filtered through a 0.22-μm membrane.