Summary of Study ST003361
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002087. The data can be accessed directly via it's Project DOI: 10.21228/M8V825 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003361 |
| Study Title | Bile acid–induced gut mitochondrial dysfunction promotes Enterobacteriaceae colonization and associates with dysbiosis in Crohn's disease |
| Study Summary | Here, we investigated whether bile acids influence gut colonization by Enterobacteriaceae. In an external human dataset, we found association between mucosal Enterobacteriaceae and the expression of mitochondrial damage–related genes. In a murine model, increased intestinal BA availability enhanced colonization by E. coli in an oxygen-dependent manner. Overall, this study establishes BAs as a potential bridge that facilitates interactions between commensals and the host epithelium, laying the essential foundation for future investigations into various intestinal diseases. |
| Institute | University of British Columbia |
| Last Name | Finlay |
| First Name | Brett |
| Address | office: MSL 333 lab: MSL 363 |
| bfinlay@msl.ubc.ca | |
| Phone | 604-822-2210 |
| Submit Date | 2024-07-30 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-08-05 |
| Release Version | 1 |
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Sample Preparation:
| Sampleprep ID: | SP003489 |
| Sampleprep Summary: | Murine feces were homogenized in 100% methanol (50 mg/mL) and spun (13,500 rpm, 10 mins) to collect BA-containing supernatant. Extracted samples were resuspended using 100% methanol before LC-MS analysis. |
