Summary of Study ST004042

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002534. The data can be accessed directly via it's Project DOI: 10.21228/M83G11 This work is supported by NIH grant, U2C- DK119886.

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Study ID	ST004042
Study Title	Untargeted Metabolomics Identifies Oncometabolites Induced by P2-HNF4α Overexpression in Hepatocytes
Study Summary	This study explores the metabolic impact of P2-HNF4α overexpression in primary mouse hepatocytes. Using untargeted metabolomics, we compared metabolite profiles between control and P2-HNF4α-overexpressing cells to identify metabolic pathways potentially altered in liver disease and HCC.
Institute	University of Tennessee Health Science Center
Department	IMM
Laboratory	Mahan Lab
Last Name	Fekry
First Name	Baharan
Address	1825 Pressler St, Houston TX 77030. USA.
Email	Baharan.Fekry@uth.tmc.edu
Phone	18434693199
Submit Date	2025-07-03
Analysis Type Detail	LC-MS
Release Date	2025-08-05
Release Version	1

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Sample Preparation:

Sampleprep ID:	SP004194
Sampleprep Summary:	Samples were diluted in a solution containing 25% acetonitrile, 75% water, and 0.1% formic acid prior to LC-MS analysis. The diluted samples were injected into an Agilent 1200 Series HPLC system coupled to an Agilent 6538 UHD Accurate-Mass Q-TOF mass spectrometer. Chromatographic separation was performed using an Agilent ZORBAX Extend-C18 Rapid Resolution HT column (2.1 × 50 mm, 1.8 µm) under a 20-minute gradient of 25% to 90% Buffer B (80% acetonitrile, 20% water, 0.1% formic acid) at a flow rate of 0.2 mL/min.

Sampleprep ID:

SP004194

Sampleprep Summary:

Samples were diluted in a solution containing 25% acetonitrile, 75% water, and 0.1% formic acid prior to LC-MS analysis. The diluted samples were injected into an Agilent 1200 Series HPLC system coupled to an Agilent 6538 UHD Accurate-Mass Q-TOF mass spectrometer. Chromatographic separation was performed using an Agilent ZORBAX Extend-C18 Rapid Resolution HT column (2.1 × 50 mm, 1.8 µm) under a 20-minute gradient of 25% to 90% Buffer B (80% acetonitrile, 20% water, 0.1% formic acid) at a flow rate of 0.2 mL/min.