Summary of study ST000337

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000269. The data can be accessed directly via it's Project DOI: 10.21228/M81307 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000337
Study TitleMetabolomics Approach to Allograft Assessment in Liver Transplantation
Study TypeRetrospective analysis of biobanked liver tissue from organ donors
Study SummaryThis pilot study is designed to apply several types of metabolomic analysis for liver allograft assessment with the aim of identifying candidate biomarkers for allograft function and to develop a methodology that could be applied to larger scale studies. The three main categories of metabolomic analysis are reflected in each of the specific aims, including a targeted profiling of central carbon metabolism, open lipidomic and metabolomic profiling for hypothesis generation and MALDI-IMS for tissue-based spatial analysis. Each of these approaches offers potential benefits that could be optimized in a protocol for larger scale studies depending the results of the pilot investigations.
Institute
Ochsner Multi-Organ Transplant Institute
DepartmentSECIM
LaboratoryAbdominal Organ Transplantation
Last NameSeal
First NameJohn
Address1514 Jefferson Highway, New Orleans, LA 70121
EmailJohn.Seal@ochsner.org
Phone504-232-4253
Submit Date2016-01-17
Num Groups3
Total SubjectsTargeted analysis and open profiling: Control group - standard criteria donor (N=15); Experimental group - donation-after-cardiac-death donors (N=10). MALDI-IMS - standard criteria donor (N=10)
Analysis Type DetailLC-MS
Release Date2017-01-17
Release Version1
John Seal John Seal
https://dx.doi.org/10.21228/M81307
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Subject:

Subject ID:SU000357
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Genotype Strain:Not applicable
Age Or Age Range:Variable
Weight Or Weight Range:Variable
Height Or Height Range:Variable
Gender:Variable
Human Race:Variable
Human Ethnicity:Variable
Human Trial Type:Not applicable
Human Lifestyle Factors:Not applicable
Human Medications:Not applicable
Human Prescription Otc:Not applicable
Human Smoking Status:Not applicable
Human Alcohol Drug Use:Not applicable
Human Nutrition:Not applicable
Human Inclusion Criteria:Deceased organ donor with consent for use of tissue for research
Human Exclusion Criteria:None
Animal Animal Supplier:in house/in house
Subject Comments:Liver biopsy is routinely performed on livers used for solid organ transplantation. The tissue is from decedent subjects. Consent for use of tissue is obtained at the time of organ donation by the local organ procurement organization.
Species Group:Human
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