Summary of Study ST001336

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000900. The data can be accessed directly via it's Project DOI: 10.21228/M8BX09 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001336
Study TitleEffect of high-fat diet and bile acid treatment on serum and tissue lipidomes in mice
Study SummaryWe analyzed mouse serum and esophageal tissue samples from a mouse dietary intervention experiment. Briefly, C57BL/6 mice (n=44) were divided into 4 groups (n=11 per group) and fed High-fat diet (HFD), 0.2% deoxycholic acid (DCA) in drinking water, both, or left as control for 9 months. For quality control,TQC samples and blanks were also included in the analysis. The two treatments were selected to demonstrate the ability of lipidomics to detect gross changes induced by HFD in the serum and tissue lipidomes, as well as specific/minor changes induced by the secondary bile acid (DCA) through regulation of liver lipid metabolism. The serum and tissue samples were analyzed using targeted and untargeted lipidomics methods. The targeted serum lipidomics data has previously been uploaded as part of study ST001323.
Institute
QIMR Berghofer Medical Research Institute
Last NameMolendijk
First NameJeffrey
Address300 Herston Road, Herston, QLD, 4006, Australia
Emailjeffrey.molendijk@qimrberghofer.edu.au
Phone+61738453992
Submit Date2020-03-26
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2020-04-27
Release Version1
Jeffrey Molendijk Jeffrey Molendijk
https://dx.doi.org/10.21228/M8BX09
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Subject:

Subject ID:SU001410
Subject Type:Mammal
Subject Species:Mus musculus
Taxonomy ID:10090
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