Summary of Study ST001748

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001120. The data can be accessed directly via it's Project DOI: 10.21228/M8XM6R This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001748
Study TitleRationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
Study TypeTargeted metabolomics
Study SummaryGUT103 and GUT108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients; they address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. Systematic colonization experiments in colitis mouse models were performed to test their therapeutic effects. Targeted fecal metabolomics data uploaded here of bile acids, short-chain fatty acids, and tryptophan metabolites provides a unique metabolome perspective for evaluation of the therapeutic potential of GUT103 and GUT108.
Institute
University of North Carolina at Chapel Hill
LaboratoryGusto Global LLC.
Last NameLai
First NameYunjia
Address1104 MHRC, 135 Dauer Drive, Chapel Hill, NC 27599, USA
Emaillai7@live.unc.edu
Phone+1 919-480-5489
Submit Date2021-04-22
Num Groups12
PublicationsNature Communications
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailGC-MS/LC-MS
Release Date2021-04-30
Release Version1
Yunjia Lai Yunjia Lai
https://dx.doi.org/10.21228/M8XM6R
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Subject:

Subject ID:SU001825
Subject Type:Mammal
Subject Species:Mus musculus
Taxonomy ID:10090
Genotype Strain:GF 129SvEv background IL-10-deficient mice (Il10-/-); Il10-eGFP-reporter (Il10+/eGFP) mice (on a C57BL/6J background)
Age Or Age Range:8-12 week old
Animal Animal Supplier:8-12 week-age GF 129SvEv background IL-10-deficient mice (Il10-/-) were obtained from University of North Carolina National Gnotobiotic Rodent Resource Center; Il10-eGFP-reporter (Il10+/eGFP) mice on a C57BL/6J background mice were originally provided by Dr. C. L. Karp (Global Health, Bill & Melinda Gates Foundation, USA)
Animal Housing:Germ-free and gnotobiotic conditions at National Gnotobiotic Rodent Resource Center, University of North Carolina
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