Summary of Study ST001935

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001224. The data can be accessed directly via it's Project DOI: 10.21228/M8H12N This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001935
Study TitleMetabolomic profiling of spontaneous macaque model for diabetes mellitus
Study SummaryThe prevalence of diabetes mellitus has been increasing for decades worldwide. To develop safe and potent therapeutics, insights into the mechanisms underlying its pathogenesis are urgently needed. We reported the multi-omics profiling of the liver and sera of both peripheral blood and hepatic portal vein blood from Macaca fascicularis with spontaneous diabetes mellitus with a chow diet. The other two groups of the monkeys fed with chow diet and high-sugar high-fat (HSHF) diet, respectively, were included for comparison. These multi-omics datasets can provide a comprehensive picture of the molecular changes caused by diabetes in primates. Analyses of various omics datasets revealed the alterations of high consistency. Correlation between transcripts and proteins derived from the same genes was observed across individuals for most genes, especially the ones of differential expression. As a result, we found that distinct patterns of the metabolome, proteome, and transcriptome between spontaneous diabetes and HSHF diet-induced diabetes compared with healthy individuals.
Institute
Xiamen University
Last NameYang
First NameZhu
AddressOEW901, Oen Hall Building West Wing,, Ho Sin Hang Campus, Hong Kong Baptist University
Emailyangzhu@gmail.com
Phone(+852)34115162
Submit Date2021-09-18
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailGC-MS
Release Date2022-02-19
Release Version1
Zhu Yang Zhu Yang
https://dx.doi.org/10.21228/M8H12N
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Subject:

Subject ID:SU002013
Subject Type:Mammal
Subject Species:Macaca fascicularis
Taxonomy ID:9541
Age Or Age Range:16.3 - 18.8 yo
Weight Or Weight Range:5.73 - 10.56 kg
Gender:Male
Animal Animal Supplier:Guangzhou Huazhen Biosciences Co., Ltd, Guangzhou
Animal Housing:Guangzhou Huazhen Biosciences Co., Ltd, Guangzhou
Animal Light Cycle:12-h/12-h light-dark cycle
Animal Feed:normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), or high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol)
Animal Inclusion Criteria:spontaneous diabetes mellitus and HFHS food-fed
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