Summary of study ST000244

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000197. The data can be accessed directly via it's Project DOI: 10.21228/M8XK51 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000244
Study TitleMetabolomic Diagnosis in Horse
Study Typecomparison
Study SummaryIn this project we will investigate the feasibility of metabolomics and to characterize the diversity of “metabotypes” in the horse, towards discovery of markers and pathways associated with obesity and insulin resistance in the equine model. The collaborative team of researchers assembled for this work have identified horses severely affected with Equine Metabolic syndrome, often characterized by obesity and hyperinsulinemia. These animals are all from the Arabian breed, to control for some genetic background. Horses are age, sex and farm of residence matched with a control animal whenever possible. Carefully controlled collection protocols were utilized to ensure minimal variability in sample age and quality. Blood plasma is submitted for both global LC-MS analysis through the SECIM core facilities. This discovery-based approach will begin to generate new targets for the development of novel therapeutic interventions for the treatment and prevention of obesity, type-2 diabetes as well as related secondary conditions in both humans and horses. Finally, as the first dataset of its kind in the horse, we may also be able to highlight promising new biomarkers for veterinary diagnostic use.
Institute
University of Florida
Last NameBrooks
First NameSamantha
Emailsamantha.brooks@ufl.edu
Submit Date2015-10-13
Num Groups3
Total Subjects51
Raw Data AvailableYes
Raw Data File Type(s).raw
Analysis Type DetailLC-MS
Release Date2016-09-23
Release Version1
Samantha Brooks Samantha Brooks
https://dx.doi.org/10.21228/M8XK51
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Treatment:

Treatment ID:TR000275
Treatment Summary:Blood was collected from the jugular vein and processed for serum, plasma, and DNA using standard procedures. To minimize circadian and meal associated effects on blood parameters, samples were collected in the morning prior to feeding concentrated rations. Care was taken to minimize stress to the animals, and no special treatments were given. Body measures were also gathered on each animal to capture regional adiposity and body size using a well optimized protocol, as well as body condition scores according to the Henneke system [numerical scores of 1 for emaciated to 9 for extremely obese]. Detailed diets, exercise regimes and a complete health history on each individual were recorded. Study animals are privately-owned, live on several farms in the central Florida area, and may have naturaly aquired disease. Based on the collected observations each horse is assigned to one of three diagnostic groups: 1) Normal Control, 2)Equine Metabolic Syndrome and 3)EMS- under treatment.
Treatment Protocol Filename:treatment.txt
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