Summary of Study ST000261

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000212. The data can be accessed directly via it's Project DOI: 10.21228/M80C7B This work is supported by NIH grant, U2C- DK119886.

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Study ID	ST000261
Study Title	1H NMR metabolomics study of spleen from C57BL/6 mice exposed to gamma radiation
Study Type	Tissue Extracts Comparison
Study Summary	Tissue extracts from exposure to gamma radiation mouse spleen and controls were compared via NMR based metabolomic analysis
Institute	Pacific Northwest National Laboratory
Department	Fundamental & Computational Sciences
Last Name	Hu
First Name	Jianzhi
Address	--
Email	jianzhi.hu@pnnl.gov
Phone	--
Submit Date	2015-10-26
Raw Data Available	Yes
Raw Data File Type(s)	fid
Uploaded File Size	24M
Analysis Type Detail	NMR
Release Date	2015-10-26
Release Version	1

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Treatment:

Treatment ID:	TR000295
Treatment Summary:	A total of 17 seven-week-old C57BL/6 female mice were randomly grouped before total body being exposed to gamma irradiation using a high activity gamma source (1250 keV 60Co). The linear energy transfer (LET) associated with these fields is in the range of 0.2-2 keV/?m. For the total body gamma radiation, the animals were isolated to the corner of their polymer cages, placed at a minimum of 100 cm from the collimated 6000 Ci 60Co source, and then irradiated to the proposed dosage. The resulting absorbed dose rate at approximately 600 mg/cm2 depth was 0.83Gy/min relative to tissue. Groups of mice were exposed to radiation doses of 0Gy (control, n=8), 3.0Gy (n=5) and 7.8Gy (n=4). After 4 days post exposure, mice were sacrificed with 70/30 CO2/O2 .

Treatment ID:

TR000295

Treatment Summary:

A total of 17 seven-week-old C57BL/6 female mice were randomly grouped before total body being exposed to gamma irradiation using a high activity gamma source (1250 keV 60Co). The linear energy transfer (LET) associated with these fields is in the range of 0.2-2 keV/?m. For the total body gamma radiation, the animals were isolated to the corner of their polymer cages, placed at a minimum of 100 cm from the collimated 6000 Ci 60Co source, and then irradiated to the proposed dosage. The resulting absorbed dose rate at approximately 600 mg/cm2 depth was 0.83Gy/min relative to tissue. Groups of mice were exposed to radiation doses of 0Gy (control, n=8), 3.0Gy (n=5) and 7.8Gy (n=4). After 4 days post exposure, mice were sacrificed with 70/30 CO2/O2 .