Summary of Study ST001251

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000838. The data can be accessed directly via it's Project DOI: 10.21228/M8C671 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001251
Study TitleThe effects of a training program encompassing cold exposure, breathing exercises, and meditation on plasma metabomics during experimental human endotoxemia
Study TypeExperimental human endotoxemia study
Study SummaryStudy to investigate the effects of a training program encompassing cold exposure, breathing exercises, and meditation on plasma metabolomic during experimental human endotoxemia.
Institute
Radboud University Medical Centre
DepartmentIntensive Care Medicine
LaboratoryMetabolomic Discoveries (acquired by Metabolon in September 2017)
Last NameKox
First NameMatthijs
AddressIntensive Care Medicine (710), Geert Grooteplein 10
Emailmatthijs.kox@radboudumc.nl
Phone243653881
Submit Date2019-09-16
Num Groups2
Total Subjects24
Num Males24
Analysis Type DetailLC-MS
Release Date2019-10-04
Release Version1
Matthijs Kox Matthijs Kox
https://dx.doi.org/10.21228/M8C671
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Treatment:

Treatment ID:TR001334
Treatment Summary:The subjects were randomly allocated to the trained group (n=12) or the control group (n=12) by the opening of sealed envelopes prepared by unblinded staff not involved in the study. The trained group underwent a 10-day training program provided by Dutch individual Wim Hof, which consisted of three main elements: meditation, exposure to cold, and breathing exercises (see https://www.pnas.org/content/111/20/7379.long for a detailed description). After completion of the training, subjects underwent experimental human endotoxemia at our intensive care research unit, consisting of administration of an intravenous bolus of 2 ng/kg of US Standard Reference Escherichia coli endotoxin (E. coli O:113 [LPS], Clinical Center Reference Endotoxin; National Institutes of Health, Bethesda, MD, USA). The experimental human endotoxemia protocol is provided in detail elsewhere (https://www.ncbi.nlm.nih.gov/pubmed/29936295; https://www.sciencedirect.com/science/article/pii/S0300908418301718?via%3Dihub). The control group did not undergo any training procedures and also underwent experimental human endotoxemia. Subjects in the trained group started practicing the breathing exercises acquired during the training program 30 minutes before LPS administration until two-and-a-half hours afterwards. The control group did not practice any techniques throughout the endotoxemia experiment. As described in detail elsewhere (https://www.pnas.org/content/111/20/7379.long), the breathing techniques consisted of two exercises. In brief, the first exercise comprised cycles of vigorous hyperventilation (approximately 30 breaths) followed by breath holding for several minutes at the discretion of the subject. The second exercise was similar, but at the end of the hyperventilation period, breath was only held for 10 seconds during all body muscles were tightened.
Treatment:Nonpharmacological training intervention
Treatment Compound:n/a.
Treatment Route:n/a.
Treatment Dose:n/a.
Treatment Dosevolume:n/a.
Treatment Doseduration:10 days
Treatment Vehicle:control group
Human Fasting:Yes, 12 hours before obtaining the first sample.
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