Summary of Study ST001332
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000904. The data can be accessed directly via it's Project DOI: 10.21228/M8TX11 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001332 |
Study Title | LCMS lipid and acyl-carnitine analysis |
Study Summary | LCMS Lipidomics and acyl-carnitine analysis. |
Institute | University of Cambridge |
Laboratory | CMaLL |
Last Name | Jenkins |
First Name | Benjamin |
Address | Department of Biochemistry, University of Cambridge, c/o Level 4, Pathology Building |
bjj25@medschl.cam.ac.uk | |
Phone | 07731103718 |
Submit Date | 2020-01-09 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2020-03-30 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR001421 |
Treatment Summary: | Parental exposure to environmental stress can program adaptive changes in offspring in diverse organisms (1–4). The mechanisms by which parental exposure to environmental stresses can program predictive adaptive responses in offspring remain almost completely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a natural pathogen of the nematode Caenorhabditis elegans and that parental exposure of C. elegans to P. vranovensis promotes offspring resistance to infection. This adaptation can be transmitted transgenerationally such that infection of adults can enhance the immunity of their descendants four generations later. We find that parental infection by P. vranovensis results in increased expression of the cysteine synthases CYSL-1 and CYSL-2 and the regulator of hypoxia inducible factor RHY-1 in progeny, that the expression of these three genes in offspring is required for adaptation to P. vranovensis, and that the expression of these genes is regulated by the WD40 repeat protein WDR-23. |