Summary of Study ST001332

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000904. The data can be accessed directly via it's Project DOI: 10.21228/M8TX11 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001332
Study TitleLCMS lipid and acyl-carnitine analysis
Study SummaryLCMS Lipidomics and acyl-carnitine analysis.
Institute
University of Cambridge
LaboratoryCMaLL
Last NameJenkins
First NameBenjamin
AddressDepartment of Biochemistry, University of Cambridge, c/o Level 4, Pathology Building
Emailbjj25@medschl.cam.ac.uk
Phone07731103718
Submit Date2020-01-09
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2020-03-30
Release Version1
Benjamin Jenkins Benjamin Jenkins
https://dx.doi.org/10.21228/M8TX11
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Treatment:

Treatment ID:TR001421
Treatment Summary:Parental exposure to environmental stress can program adaptive changes in offspring in diverse organisms (1–4). The mechanisms by which parental exposure to environmental stresses can program predictive adaptive responses in offspring remain almost completely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a natural pathogen of the nematode Caenorhabditis elegans and that parental exposure of C. elegans to P. vranovensis promotes offspring resistance to infection. This adaptation can be transmitted transgenerationally such that infection of adults can enhance the immunity of their descendants four generations later. We find that parental infection by P. vranovensis results in increased expression of the cysteine synthases CYSL-1 and CYSL-2 and the regulator of hypoxia inducible factor RHY-1 in progeny, that the expression of these three genes in offspring is required for adaptation to P. vranovensis, and that the expression of these genes is regulated by the WD40 repeat protein WDR-23.
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