Summary of Study ST001399
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000959. The data can be accessed directly via it's Project DOI: 10.21228/M8QX3V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001399 |
Study Title | Activation of ectopic olfactory receptor 544 induces GLP-1 secretion, alters gut microbiome, and improves intestinal permeability. |
Study Type | Fecal metabolome |
Study Summary | Metabolome data set from mouse fecal samples Group - WT_AZA: fecal samples from wild type mouse fed with high fat diet and azelaic acid (0.05%, w/w) Group - WT_DW: fecal samples from wild type mouse fed with high fat diet Group - KO_AZA: fecal samples from Olfr544 receptor knock out mouse fed with high fat diet and azelaic acid (0.05%, w/w) Group - KO_DW: fecal samples from Olfr544 receptor knock out mouse fed with high fat diet |
Institute | Korea University |
Last Name | Kim |
First Name | Jungyeon |
Address | 145, Anam-ro, Seongbuk-gu, Seoul, Seoul, 02841, Korea, South |
kim131812@korea.ac.kr | |
Phone | 821082248015 |
Submit Date | 2020-06-07 |
Raw Data Available | Yes |
Raw Data File Type(s) | cdf |
Analysis Type Detail | GC-MS |
Release Date | 2020-06-30 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR001488 |
Treatment Summary: | The mice were fed on 60% high fat diet (HFD) for 4 weeks and subsequently randomly assigned into the test or vehicle group. HFD used in this study is rodent diet containing 60% of calories from fat (D12492, Research Diets, Inc). The mice in the test group were fed with a HFD and 0.05% (w/w) AzA for 6 weeks or a HFD and orally administered AzA (50 mg/kg body weight) for 8 weeks. The former feeding was to confirm antiobesogenic effects of AzA in diet and the latter was to investigate microbiome and metabolomic analyses. The mice in the vehicle group were administered ddH2O. The body weight and food intake of the mice were measured twice a week. Mice were fasted overnight before being sacrificed. |