Summary of Study ST001680

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001079. The data can be accessed directly via it's Project DOI: 10.21228/M8797T This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Study ID	ST001680
Study Title	Metabolome of NAFLD in high fat diet mouse model
Study Summary	We investigated the effects of a RAR beta 2 agonist, AC261066, on the hepatic metabolites changed in high fat fed NAFLD mouse model. We suggest that AC261066 has potential therapeutic relevance for the prevention/treatment of NAFLD and NASH.
Institute	Weill Cornell Medicine
Last Name	Gudas
First Name	Lorraine
Address	1300 York Ave
Email	chl2029@med.cornell.edu
Phone	646-3094389
Submit Date	2021-01-27
Raw Data Available	Yes
Raw Data File Type(s)	d
Analysis Type Detail	LC-MS
Release Date	2022-01-27
Release Version	1

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Treatment:

Treatment ID:	TR001770
Treatment Summary:	Wild-type (wt) male C57BL/6 mice (6-7 weeks old) were maintained on either a standard laboratory chow (Con) diet with 13 % kcal fat (diet no. 5053, Pico Diet, St. Louis, MO), or a high fat diet (HFD) with 60% kcal from fat (diet no. 58125, Test Diet, Inc., St. Louis, MO) for 4 months. Two months after the start of the HFD, the mice were further split into three groups for 2 months to remain on (i) chow plus drinking water with 0.2 % DMSO; (ii) HFD plus drinking water containing 0.2 % DMSO; or (iii) HFD plus 3 mg AC261066 per 100 ml drinking water with 0.2 % DMSO.

Treatment ID:

TR001770

Treatment Summary:

Wild-type (wt) male C57BL/6 mice (6-7 weeks old) were maintained on either a standard laboratory chow (Con) diet with 13 % kcal fat (diet no. 5053, Pico Diet, St. Louis, MO), or a high fat diet (HFD) with 60% kcal from fat (diet no. 58125, Test Diet, Inc., St. Louis, MO) for 4 months. Two months after the start of the HFD, the mice were further split into three groups for 2 months to remain on (i) chow plus drinking water with 0.2 % DMSO; (ii) HFD plus drinking water containing 0.2 % DMSO; or (iii) HFD plus 3 mg AC261066 per 100 ml drinking water with 0.2 % DMSO.