Summary of Study ST001907

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001201. The data can be accessed directly via it's Project DOI: 10.21228/M8G69Q This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST001907
Study Title	Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganisation of respiratory chain content
Study Type	Multi Omics
Study Summary	Lipidomic analysis of muscle mitochondrial isolates. 10 men with repeated measures.
Institute	Baker Heart and Diabetes Institute
Department	Meteabolomics
Laboratory	Meteabolomics
Last Name	Huynh
First Name	Kevin
Address	75 Commercial Road
Email	kevin.huynh@baker.edu.au
Phone	0385321537
Submit Date	2021-08-15
Num Groups	1
Total Subjects	10
Num Males	10
Raw Data Available	Yes
Raw Data File Type(s)	mzML
Analysis Type Detail	LC-MS
Release Date	2021-10-18
Release Version	1

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Treatment:

Treatment ID:	TR001997
Treatment Summary:	Training intervention. All training sessions were performed on an electronically braked cycle ergometer (Velotron, RacerMate, USA), following an 8-min warm up (see 20k-TT) and consisted of HIIT (2:1 work-to-rest ratio). Training intensity was set relative to ẆLT (rather than ẆPeak) so as to induce similar metabolic and cardiac stresses amongst participants of differing fitness levels75. Exercise intensity was maintained between ẆLT and ẆPeak throughout the entire study so that training volume was the only manipulated variable between the 3 phases. NVT phase. This consisted of 6 HIIT sessions within 2 weeks of 5 to 7 4-min cycling intervals interspersed with a 2-min recovery at 60 W. Exercise intensities were defined as [ẆLT + x(ẆPeak-ẆLT)], with x increasing from 0.5 to 0.7 throughout the phase. HVT phase. Participants performed HIIT twice a day for 20 consecutive days; training sessions consisted of either 7 to 10 4-min intervals interspersed with a 2-min recovery at 60 W at intensities ranging from [ẆLT + 0.5(ẆPeak-ẆLT)] to [ẆLT + 0.8(ẆPeak-ẆLT)], or 15 to 20 2-min intervals at intensities ranging from [ẆLT + 0.5(ẆPeak-ẆLT)] to [ẆLT + 0.95(ẆPeak-ẆLT)], interspersed with a 1-min recovery at 60 W. Single session duration increased from ~45 min to 60 min. RVT phase. The RVT phase consisted of 6 HIIT sessions in 6 days; participants performed 10, 9, 8, 7, 6, and 4, 4-min intervals interspersed with a 2-min recovery at 60 W, at an intensity of [ẆLT + x(ẆPeak- ẆLT)], with x increasing from 0.5 to 0.7 throughout the phase.

Treatment ID:

TR001997

Treatment Summary:

Training intervention. All training sessions were performed on an electronically braked cycle ergometer (Velotron, RacerMate, USA), following an 8-min warm up (see 20k-TT) and consisted of HIIT (2:1 work-to-rest ratio). Training intensity was set relative to ẆLT (rather than ẆPeak) so as to induce similar metabolic and cardiac stresses amongst participants of differing fitness levels75. Exercise intensity was maintained between ẆLT and ẆPeak throughout the entire study so that training volume was the only manipulated variable between the 3 phases. NVT phase. This consisted of 6 HIIT sessions within 2 weeks of 5 to 7 4-min cycling intervals interspersed with a 2-min recovery at 60 W. Exercise intensities were defined as [ẆLT + x(ẆPeak-ẆLT)], with x increasing from 0.5 to 0.7 throughout the phase. HVT phase. Participants performed HIIT twice a day for 20 consecutive days; training sessions consisted of either 7 to 10 4-min intervals interspersed with a 2-min recovery at 60 W at intensities ranging from [ẆLT + 0.5(ẆPeak-ẆLT)] to [ẆLT + 0.8(ẆPeak-ẆLT)], or 15 to 20 2-min intervals at intensities ranging from [ẆLT + 0.5(ẆPeak-ẆLT)] to [ẆLT + 0.95(ẆPeak-ẆLT)], interspersed with a 1-min recovery at 60 W. Single session duration increased from ~45 min to 60 min. RVT phase. The RVT phase consisted of 6 HIIT sessions in 6 days; participants performed 10, 9, 8, 7, 6, and 4, 4-min intervals interspersed with a 2-min recovery at 60 W, at an intensity of [ẆLT + x(ẆPeak- ẆLT)], with x increasing from 0.5 to 0.7 throughout the phase.