Summary of Study ST001907

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001201. The data can be accessed directly via it's Project DOI: 10.21228/M8G69Q This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001907
Study TitleTraining-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganisation of respiratory chain content
Study TypeMulti Omics
Study SummaryLipidomic analysis of muscle mitochondrial isolates. 10 men with repeated measures.
Baker Heart and Diabetes Institute
Last NameHuynh
First NameKevin
Address75 Commercial Road
Submit Date2021-08-15
Num Groups1
Total Subjects10
Num Males10
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2021-10-18
Release Version1
Kevin Huynh Kevin Huynh application/zip

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Treatment ID:TR001997
Treatment Summary:Training intervention. All training sessions were performed on an electronically braked cycle ergometer (Velotron, RacerMate, USA), following an 8-min warm up (see 20k-TT) and consisted of HIIT (2:1 work-to-rest ratio). Training intensity was set relative to ẆLT (rather than ẆPeak) so as to induce similar metabolic and cardiac stresses amongst participants of differing fitness levels75. Exercise intensity was maintained between ẆLT and ẆPeak throughout the entire study so that training volume was the only manipulated variable between the 3 phases. NVT phase. This consisted of 6 HIIT sessions within 2 weeks of 5 to 7 4-min cycling intervals interspersed with a 2-min recovery at 60 W. Exercise intensities were defined as [ẆLT + x(ẆPeak-ẆLT)], with x increasing from 0.5 to 0.7 throughout the phase. HVT phase. Participants performed HIIT twice a day for 20 consecutive days; training sessions consisted of either 7 to 10 4-min intervals interspersed with a 2-min recovery at 60 W at intensities ranging from [ẆLT + 0.5(ẆPeak-ẆLT)] to [ẆLT + 0.8(ẆPeak-ẆLT)], or 15 to 20 2-min intervals at intensities ranging from [ẆLT + 0.5(ẆPeak-ẆLT)] to [ẆLT + 0.95(ẆPeak-ẆLT)], interspersed with a 1-min recovery at 60 W. Single session duration increased from ~45 min to 60 min. RVT phase. The RVT phase consisted of 6 HIIT sessions in 6 days; participants performed 10, 9, 8, 7, 6, and 4, 4-min intervals interspersed with a 2-min recovery at 60 W, at an intensity of [ẆLT + x(ẆPeak- ẆLT)], with x increasing from 0.5 to 0.7 throughout the phase.